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Pain in Psychiatric Disorders

Overview of attention for book
Attention for Chapter: Pain, Depression and Inflammation: Are Interconnected Causative Factors Involved?
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41 Mendeley
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Chapter title
Pain, Depression and Inflammation: Are Interconnected Causative Factors Involved?
Book title
Pain in Psychiatric Disorders
Published in
Modern trends in pharmacopsychiatry, September 2015
DOI 10.1159/000435930
Pubmed ID
Book ISBNs
978-3-31-805573-3, 978-3-31-805574-0

Leonard, Brian E, Brian E. Leonard


Co-morbid depression and chronic pain are highly prevalent. The purpose of this review is to examine the role of chronic inflammation as a common mediator of these co-morbidities. Dysfunctional bidirectional pathways between the brain and the immune, endocrine and neurotransmitter systems have been extensively described and implicated in pain and psychiatric disorders. This short review therefore accesses the evidence in favour of the psychoneuroendocrine hypothesis of psychiatric disorders under three main headings: (1) by illustrating how different types of stress play a crucial role in initiating chronic inflammation in major depression, (2) by accessing the evidence that pain is frequently an important component of, and an initiator of, depression, and (3) considering the evidence that chronic inflammation provides an important link between chronic pain and depression, and the possible cellular mechanisms involved in this process. By understanding the critical role that chronic inflammation plays in pain and depression, novel approaches to the development of drugs may emerge that offer improvements in treatment.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
New Zealand 1 2%
Unknown 40 98%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 8 20%
Student > Ph. D. Student 7 17%
Professor > Associate Professor 3 7%
Student > Master 3 7%
Student > Postgraduate 2 5%
Other 7 17%
Unknown 11 27%
Readers by discipline Count As %
Medicine and Dentistry 11 27%
Psychology 4 10%
Biochemistry, Genetics and Molecular Biology 3 7%
Agricultural and Biological Sciences 3 7%
Nursing and Health Professions 2 5%
Other 4 10%
Unknown 14 34%