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Host genetic factors in American cutaneous leishmaniasis: a critical appraisal of studies conducted in an endemic area of Brazil

Overview of attention for article published in Memórias do Instituto Oswaldo Cruz, May 2014
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Title
Host genetic factors in American cutaneous leishmaniasis: a critical appraisal of studies conducted in an endemic area of Brazil
Published in
Memórias do Instituto Oswaldo Cruz, May 2014
DOI 10.1590/0074-0276140028
Pubmed ID
Authors

Léa Cristina Castellucci, Lucas Frederico de Almeida, Sarra Elisabeth Jamieson, Michaela Fakiola, Edgar Marcelino de Carvalho, Jenefer Mary Blackwell

Abstract

American cutaneous leishmaniasis (ACL) is a vector-transmitted infectious disease with an estimated 1.5 million new cases per year. In Brazil, ACL represents a significant public health problem, with approximately 30,000 new reported cases annually, representing an incidence of 18.5 cases per 100,000 inhabitants. Corte de Pedra is in a region endemic for ACL in the state of Bahia (BA), northeastern Brazil, with 500-1,300 patients treated annually. Over the last decade, population and family-based candidate gene studies were conducted in Corte de Pedra, founded on previous knowledge from studies on mice and humans. Notwithstanding limitations related to sample size and power, these studies contribute important genetic biomarkers that identify novel pathways of disease pathogenesis and possible new therapeutic targets. The present paper is a narrative review about ACL immunogenetics in BA, highlighting in particular the interacting roles of the wound healing gene FLI1 with interleukin-6 and genes SMAD2 and SMAD3 of the transforming growth factor beta signalling pathway. This research highlights the need for well-powered genetic and functional studies on Leishmania braziliensis infection as essential to define and validate the role of host genes in determining resistance/susceptibility regarding this disease.

Mendeley readers

The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 3 4%
Unknown 66 96%

Demographic breakdown

Readers by professional status Count As %
Student > Master 14 20%
Student > Ph. D. Student 11 16%
Student > Bachelor 10 14%
Researcher 5 7%
Student > Doctoral Student 3 4%
Other 9 13%
Unknown 17 25%
Readers by discipline Count As %
Agricultural and Biological Sciences 16 23%
Immunology and Microbiology 9 13%
Biochemistry, Genetics and Molecular Biology 9 13%
Medicine and Dentistry 5 7%
Pharmacology, Toxicology and Pharmaceutical Science 2 3%
Other 9 13%
Unknown 19 28%