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Human IgE responses to Schistosoma mansoni and resistance to reinfection

Overview of attention for article published in Memórias do Instituto Oswaldo Cruz, January 1992
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (57th percentile)
  • Good Attention Score compared to outputs of the same age and source (69th percentile)

Mentioned by

wikipedia
1 Wikipedia page

Citations

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55 Dimensions

Readers on

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28 Mendeley
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Title
Human IgE responses to Schistosoma mansoni and resistance to reinfection
Published in
Memórias do Instituto Oswaldo Cruz, January 1992
DOI 10.1590/s0074-02761992000800014
Pubmed ID
Authors

David W. Dunne, Anthony E. Butterworth, Anthony J. C. Fulford, John H. Ouma, Robert F. Sturrock

Abstract

Schistosoma mansoni infected Kenyan patients were treated and the intensities of their reinfections were followed over the next two years. In addition, their pre- and six month post-treatment serum levels of IgG1-4, IgM, and IgE, specific for schistosomula, egg and adult worm, were measured in ELISA. No reinfection took place before six months post-treatment. Reinfection intensities varied with age; the younger children becoming reinfected at significantly higher intensities than older individuals. When antibody and reinfection levels were compared, only the six month post-treatment IgE response against adult worm correlated negatively with intensities of reinfection and, therefore, was predictive of resistance or immunity to reinfection. IgE and IgG specific Western Blots were carried out. The adult worm antigens recognized by IgE were restricted compared with the IgG responses of the same patients, although no individual antigen was uniquely recognized by the IgE isotype. A dominant 22 kDa antigen was recognized by most but not all high IgE responders. Patients with IgE responses against this antigen suffered significantly lower subsequent levels of reinfection, compared with non-responders. A monospecific rabbit antiserum against the 22 kDa adult worm antigen showed that this antigen is specifically located in the tegument of the adult worm and of 'lung' and 'liver' stage schistosomula, but is absent from the early 'skin' schistosomula. It is possible that this antigen is a target for human IgE mediated immune effector mechanisms active against the post skin stage schistosomula and that this is boosted by the death of adult worms.

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Kenya 1 4%
Australia 1 4%
Brazil 1 4%
Unknown 25 89%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 25%
Researcher 5 18%
Student > Bachelor 3 11%
Professor 3 11%
Student > Master 2 7%
Other 3 11%
Unknown 5 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 12 43%
Biochemistry, Genetics and Molecular Biology 2 7%
Medicine and Dentistry 2 7%
Social Sciences 2 7%
Nursing and Health Professions 1 4%
Other 2 7%
Unknown 7 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 December 2014.
All research outputs
#6,842,633
of 21,094,310 outputs
Outputs from Memórias do Instituto Oswaldo Cruz
#240
of 1,301 outputs
Outputs of similar age
#119,320
of 374,814 outputs
Outputs of similar age from Memórias do Instituto Oswaldo Cruz
#12
of 42 outputs
Altmetric has tracked 21,094,310 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,301 research outputs from this source. They receive a mean Attention Score of 4.4. This one is in the 42nd percentile – i.e., 42% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 374,814 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.
We're also able to compare this research output to 42 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.