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Regulatory T cells and control of the germinal centre response

Overview of attention for article published in Arthritis Research & Therapy, October 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (79th percentile)
  • Good Attention Score compared to outputs of the same age and source (73rd percentile)

Mentioned by

news
1 news outlet

Citations

dimensions_citation
33 Dimensions

Readers on

mendeley
79 Mendeley
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Title
Regulatory T cells and control of the germinal centre response
Published in
Arthritis Research & Therapy, October 2014
DOI 10.1186/s13075-014-0471-7
Pubmed ID
Authors

Ine Vanderleyden, Michelle A Linterman, Kenneth GC Smith

Abstract

Germinal centres (GCs) are specialised lymphoid microenvironments that form in secondary B-cell follicles upon exposure to T-dependent antigens. In the GC, clonal expansion, selection and differentiation of GC B cells result in the production of high-affinity plasma cells and memory B cells that provide protection against subsequent infection. The GC is carefully regulated to fulfil its critical role in defence against infection and to ensure that immunological tolerance is not broken in the process. The GC response can be controlled by a number of mechanisms, one of which is by forkhead box p3 expressing regulatory T (Treg) cells, a suppressive population of CD4+ T cells. A specialised subset of Treg cells - follicular regulatory T (Tfr) cells - form after immunisation and are able to access the GC, where they control the size and output of the response. Our knowledge of Treg cell control of the GC is expanding. In this review we will discuss recent advances in the field, with a particular emphasis on the differentiation and function of Tfr cells in the GC.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 79 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 1 1%
Peru 1 1%
Unknown 77 97%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 16 20%
Student > Ph. D. Student 15 19%
Researcher 15 19%
Student > Master 6 8%
Student > Postgraduate 4 5%
Other 9 11%
Unknown 14 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 19 24%
Immunology and Microbiology 15 19%
Medicine and Dentistry 13 16%
Biochemistry, Genetics and Molecular Biology 13 16%
Environmental Science 1 1%
Other 2 3%
Unknown 16 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 June 2019.
All research outputs
#4,836,164
of 25,374,647 outputs
Outputs from Arthritis Research & Therapy
#1,028
of 3,381 outputs
Outputs of similar age
#52,265
of 274,424 outputs
Outputs of similar age from Arthritis Research & Therapy
#16
of 64 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,381 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 274,424 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 64 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.