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Genes related to maintenance of autophagy and successful aging

Overview of attention for article published in Arquivos de Neuro-Psiquiatria, December 2018
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Genes related to maintenance of autophagy and successful aging
Published in
Arquivos de Neuro-Psiquiatria, December 2018
DOI 10.1590/0004-282x20180142
Pubmed ID

Carolina Fioroto Chaves, Diego Robles Mazzotti, Maysa Seabra Cendoroglo, Luiz Roberto Ramos, Sergio Tufik, Vanessa Cavalcante da Silva, Vânia D'Almeida


Considering aging as a phenomenon in which there is a decline in essential processes for cell survival, we investigated the autophagic and proteasome pathways in three different groups: young, older and oldest old male adults. The expression profile of autophagic pathway-related genes was carried out in peripheral blood, and the proteasome quantification was performed in plasma. No significant changes were found in plasma proteasome concentrations or in correlations between proteasome concentrations and ages. However, some autophagy- and/or apoptosis-related genes were differentially expressed. In addition, the network and enrichment analysis showed an interaction between four of the five differentially expressed genes and an association of these genes with the transcriptional process. Considering that the oldest old individuals maintained both the expression of genes linked to the autophagic machinery, and the proteasome levels, when compared with the older group, we concluded that these factors could be considered crucial for successful aging.

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Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 18 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 17%
Student > Bachelor 3 17%
Student > Master 3 17%
Other 2 11%
Student > Doctoral Student 1 6%
Other 4 22%
Unknown 2 11%
Readers by discipline Count As %
Medicine and Dentistry 5 28%
Biochemistry, Genetics and Molecular Biology 3 17%
Agricultural and Biological Sciences 2 11%
Unspecified 1 6%
Psychology 1 6%
Other 3 17%
Unknown 3 17%