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Yeast-based assay identifies novel Shh/Gli target genes in vertebrate development

Overview of attention for article published in BMC Genomics, January 2012
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Title
Yeast-based assay identifies novel Shh/Gli target genes in vertebrate development
Published in
BMC Genomics, January 2012
DOI 10.1186/1471-2164-13-2
Pubmed ID
Authors

Luis A Milla, Claudio R Cortés, Christian Hodar Q, Maritza G Oñate, Veronica Cambiazo, Shawn M Burgess, Verónica Palma

Abstract

The increasing number of developmental events and molecular mechanisms associated with the Hedgehog (Hh) pathway from Drosophila to vertebrates, suggest that gene regulation is crucial for diverse cellular responses, including target genes not yet described. Although several high-throughput, genome-wide approaches have yielded information at the genomic, transcriptional and proteomic levels, the specificity of Gli binding sites related to direct target gene activation still remain elusive. This study aims to identify novel putative targets of Gli transcription factors through a protein-DNA binding assay using yeast, and validating a subset of targets both in-vitro and in-vivo. Testing in different Hh/Gli gain- and loss-of-function scenarios we here identified known (e.g., ptc1) and novel Hh-regulated genes in zebrafish embryos.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 3%
Chile 2 3%
Canada 1 2%
Unknown 56 92%

Demographic breakdown

Readers by professional status Count As %
Researcher 11 18%
Student > Ph. D. Student 9 15%
Student > Master 8 13%
Student > Bachelor 7 11%
Student > Postgraduate 4 7%
Other 16 26%
Unknown 6 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 35 57%
Biochemistry, Genetics and Molecular Biology 10 16%
Engineering 2 3%
Neuroscience 2 3%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Other 4 7%
Unknown 7 11%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 January 2012.
All research outputs
#18,303,566
of 22,661,413 outputs
Outputs from BMC Genomics
#8,141
of 10,612 outputs
Outputs of similar age
#196,003
of 244,202 outputs
Outputs of similar age from BMC Genomics
#222
of 296 outputs
Altmetric has tracked 22,661,413 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 10,612 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
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We're also able to compare this research output to 296 others from the same source and published within six weeks on either side of this one. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.