SET SUMOylation promotes its cytoplasmic retention and induces tau pathology and cognitive impairments.
Alzforum,
Qin M, Li H, Bao J, Xia Y, Ke D, Wang Q, Liu R, Wang JZ, Zhang B, Shu X, Wang X.
Qin M, Li H, Bao J, Xia Y, Ke D, Wang Q, Liu R, Wang JZ, Zhang B, Shu X, Wang X.
In AD, decreased PP2A activity is considered an important factor in hyperphosphorylation of tau and the formation of NFTs [ 21 ].