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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Characterization of a messenger RNA polynucleotide vaccine vector.
|
|---|---|
| Published in |
Cancer Research, April 1995
|
| Pubmed ID | |
| Authors |
R M Conry, A F LoBuglio, M Wright, L Sumerel, M J Pike, F Johanning, R Benjamin, D Lu, D T Curiel |
| Abstract |
We have constructed mRNA transcripts encoding luciferase and human carcinoembryonic antigen (CEA) which are capped, polyadenylated, and stabilized by human beta-globin 5' and 3' untranslated regions. The mRNA construct encoding human CEA directed CEA expression in mouse fibroblasts in vitro following liposome-mediated transfection. The luciferase encoding mRNA transcripts mediated luciferase expression in vivo following i.m. injection. Based on the demonstration of protein expression in vitro and in vivo, the feasibility of using such a vector as a tumor vaccine was examined. In this pilot study, seven mice received 50 micrograms mRNA transcripts encoding CEA twice weekly for 5 weeks by i.m. injection followed by challenge with syngeneic, CEA-expressing tumor cells. This dose and schedule "primed" an immune response to CEA. Five of seven mRNA-immunized mice demonstrated anti-CEA antibody 3 weeks after tumor challenge whereas control mice had no evidence of antibody response. This strategy might be particularly useful to induce an immune response to a proto-oncogene product or growth factor which poses a risk of inducing malignant transformation consequent to prolonged protein expression. |
X Demographics
The data shown below were collected from the profiles of 215 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 45 | 21% |
| United States | 4 | 2% |
| Germany | 3 | 1% |
| Italy | 2 | <1% |
| Austria | 2 | <1% |
| United Kingdom | 2 | <1% |
| Canada | 1 | <1% |
| Korea, Republic of | 1 | <1% |
| Belgium | 1 | <1% |
| Other | 6 | 3% |
| Unknown | 148 | 69% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 208 | 97% |
| Scientists | 5 | 2% |
| Practitioners (doctors, other healthcare professionals) | 1 | <1% |
| Science communicators (journalists, bloggers, editors) | 1 | <1% |
Mendeley readers
The data shown below were compiled from readership statistics for 207 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 207 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 35 | 17% |
| Student > Bachelor | 34 | 16% |
| Student > Master | 23 | 11% |
| Researcher | 16 | 8% |
| Other | 9 | 4% |
| Other | 17 | 8% |
| Unknown | 73 | 35% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 39 | 19% |
| Agricultural and Biological Sciences | 20 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 17 | 8% |
| Immunology and Microbiology | 15 | 7% |
| Medicine and Dentistry | 10 | 5% |
| Other | 28 | 14% |
| Unknown | 78 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 177. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 March 2024.
All research outputs
#232,382
of 25,775,807 outputs
Outputs from Cancer Research
#108
of 18,888 outputs
Outputs of similar age
#31
of 23,830 outputs
Outputs of similar age from Cancer Research
#1
of 25 outputs
Altmetric has tracked 25,775,807 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 18,888 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.5. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 23,830 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.