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Structural comparison of tRNA m1A58 methyltransferases revealed different molecular strategies to maintain their oligomeric architecture under extreme conditions

Overview of attention for article published in BMC Molecular and Cell Biology, December 2011
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Title
Structural comparison of tRNA m1A58 methyltransferases revealed different molecular strategies to maintain their oligomeric architecture under extreme conditions
Published in
BMC Molecular and Cell Biology, December 2011
DOI 10.1186/1472-6807-11-48
Pubmed ID
Authors

Amandine Guelorget, Pierre Barraud, Carine Tisné, Béatrice Golinelli-Pimpaneau

Abstract

tRNA m(1)A58 methyltransferases (TrmI) catalyze the transfer of a methyl group from S-adenosyl-L-methionine to nitrogen 1 of adenine 58 in the T-loop of tRNAs from all three domains of life. The m(1)A58 modification has been shown to be essential for cell growth in yeast and for adaptation to high temperatures in thermophilic organisms. These enzymes were shown to be active as tetramers. The crystal structures of five TrmIs from hyperthermophilic archaea and thermophilic or mesophilic bacteria have previously been determined, the optimal growth temperature of these organisms ranging from 37°C to 100°C. All TrmIs are assembled as tetramers formed by dimers of tightly assembled dimers.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 5%
Unknown 18 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 37%
Student > Master 4 21%
Student > Bachelor 3 16%
Student > Ph. D. Student 2 11%
Professor 1 5%
Other 3 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 8 42%
Biochemistry, Genetics and Molecular Biology 4 21%
Mathematics 1 5%
Psychology 1 5%
Medicine and Dentistry 1 5%
Other 2 11%
Unknown 2 11%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 January 2012.
All research outputs
#17,285,036
of 25,371,288 outputs
Outputs from BMC Molecular and Cell Biology
#778
of 1,233 outputs
Outputs of similar age
#172,929
of 249,131 outputs
Outputs of similar age from BMC Molecular and Cell Biology
#7
of 21 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,233 research outputs from this source. They receive a mean Attention Score of 4.0. This one is in the 27th percentile – i.e., 27% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 249,131 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 19th percentile – i.e., 19% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.