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Sociodemographic, behavioral and genetic determinants of allostatic load in a Swiss population-based study

Overview of attention for article published in Psychoneuroendocrinology, May 2016
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Title
Sociodemographic, behavioral and genetic determinants of allostatic load in a Swiss population-based study
Published in
Psychoneuroendocrinology, May 2016
DOI 10.1016/j.psyneuen.2016.02.003
Pubmed ID
Authors

Dusan Petrovic, Edward Pivin, Belen Ponte, Nasser Dhayat, Menno Pruijm, Georg Ehret, Daniel Ackermann, Idris Guessous, Sandrine Estoppey Younes, Antoinette Pechère-Bertschi, Bruno Vogt, Markus Mohaupt, Pierre-Yves Martin, Fred Paccaud, Michel Burnier, Murielle Bochud, Silvia Stringhini

Abstract

Allostatic load (AL) is a marker of physiological dysregulation which reflects exposure to chronic stress. High AL has been related to poorer health outcomes including mortality. We examine here the association of socioeconomic and lifestyle factors with AL. Additionally, we investigate the extent to which AL is genetically determined. We included 803 participants (52% women, mean age 48±16years) from a population and family-based Swiss study. We computed an AL index aggregating 14 markers from cardiovascular, metabolic, lipidic, oxidative, hypothalamus-pituitary-adrenal and inflammatory homeostatic axes. Education and occupational position were used as indicators of socioeconomic status. Marital status, stress, alcohol intake, smoking, dietary patterns and physical activity were considered as lifestyle factors. Heritability of AL was estimated by maximum likelihood. Women with a low occupational position had higher AL (low vs. high OR=3.99, 95%CI [1.22;13.05]), while the opposite was observed for men (middle vs. high OR=0.48, 95%CI [0.23;0.99]). Education tended to be inversely associated with AL in both sexes(low vs. high OR=3.54, 95%CI [1.69;7.4]/OR=1.59, 95%CI [0.88;2.90] in women/men). Heavy drinking men as well as women abstaining from alcohol had higher AL than moderate drinkers. Physical activity was protective against AL while high salt intake was related to increased AL risk. The heritability of AL was estimated to be 29.5% ±7.9%. Our results suggest that generalized physiological dysregulation, as measured by AL, is determined by both environmental and genetic factors. The genetic contribution to AL remains modest when compared to the environmental component, which explains approximately 70% of the phenotypic variance.

Mendeley readers

The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Russia 1 2%
Unknown 64 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 15%
Student > Master 10 15%
Student > Ph. D. Student 10 15%
Student > Bachelor 10 15%
Other 6 9%
Other 9 14%
Unknown 10 15%
Readers by discipline Count As %
Medicine and Dentistry 18 28%
Psychology 8 12%
Nursing and Health Professions 5 8%
Social Sciences 5 8%
Neuroscience 3 5%
Other 10 15%
Unknown 16 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 February 2016.
All research outputs
#12,837,923
of 14,533,317 outputs
Outputs from Psychoneuroendocrinology
#2,424
of 2,878 outputs
Outputs of similar age
#282,071
of 342,101 outputs
Outputs of similar age from Psychoneuroendocrinology
#80
of 88 outputs
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