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Sociodemographic, behavioral and genetic determinants of allostatic load in a Swiss population-based study

Overview of attention for article published in Psychoneuroendocrinology, May 2016
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Title
Sociodemographic, behavioral and genetic determinants of allostatic load in a Swiss population-based study
Published in
Psychoneuroendocrinology, May 2016
DOI 10.1016/j.psyneuen.2016.02.003
Pubmed ID
Authors

Dusan Petrovic, Edward Pivin, Belen Ponte, Nasser Dhayat, Menno Pruijm, Georg Ehret, Daniel Ackermann, Idris Guessous, Sandrine Estoppey Younes, Antoinette Pechère-Bertschi, Bruno Vogt, Markus Mohaupt, Pierre-Yves Martin, Fred Paccaud, Michel Burnier, Murielle Bochud, Silvia Stringhini

Abstract

Allostatic load (AL) is a marker of physiological dysregulation which reflects exposure to chronic stress. High AL has been related to poorer health outcomes including mortality. We examine here the association of socioeconomic and lifestyle factors with AL. Additionally, we investigate the extent to which AL is genetically determined. We included 803 participants (52% women, mean age 48±16years) from a population and family-based Swiss study. We computed an AL index aggregating 14 markers from cardiovascular, metabolic, lipidic, oxidative, hypothalamus-pituitary-adrenal and inflammatory homeostatic axes. Education and occupational position were used as indicators of socioeconomic status. Marital status, stress, alcohol intake, smoking, dietary patterns and physical activity were considered as lifestyle factors. Heritability of AL was estimated by maximum likelihood. Women with a low occupational position had higher AL (low vs. high OR=3.99, 95%CI [1.22;13.05]), while the opposite was observed for men (middle vs. high OR=0.48, 95%CI [0.23;0.99]). Education tended to be inversely associated with AL in both sexes(low vs. high OR=3.54, 95%CI [1.69;7.4]/OR=1.59, 95%CI [0.88;2.90] in women/men). Heavy drinking men as well as women abstaining from alcohol had higher AL than moderate drinkers. Physical activity was protective against AL while high salt intake was related to increased AL risk. The heritability of AL was estimated to be 29.5% ±7.9%. Our results suggest that generalized physiological dysregulation, as measured by AL, is determined by both environmental and genetic factors. The genetic contribution to AL remains modest when compared to the environmental component, which explains approximately 70% of the phenotypic variance.

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Mendeley readers

The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Russia 1 2%
Unknown 55 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 18%
Student > Ph. D. Student 10 18%
Student > Master 9 16%
Student > Bachelor 8 14%
Other 4 7%
Other 9 16%
Unknown 6 11%
Readers by discipline Count As %
Medicine and Dentistry 15 27%
Psychology 8 14%
Nursing and Health Professions 6 11%
Social Sciences 4 7%
Biochemistry, Genetics and Molecular Biology 3 5%
Other 8 14%
Unknown 12 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 February 2016.
All research outputs
#9,815,597
of 12,289,338 outputs
Outputs from Psychoneuroendocrinology
#1,925
of 2,546 outputs
Outputs of similar age
#238,629
of 345,511 outputs
Outputs of similar age from Psychoneuroendocrinology
#79
of 90 outputs
Altmetric has tracked 12,289,338 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,546 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.2. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
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We're also able to compare this research output to 90 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.