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Relationship between deep subcutaneous abdominal adipose tissue and metabolic syndrome: a case control study

Overview of attention for article published in Diabetology & Metabolic Syndrome, February 2016
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Title
Relationship between deep subcutaneous abdominal adipose tissue and metabolic syndrome: a case control study
Published in
Diabetology & Metabolic Syndrome, February 2016
DOI 10.1186/s13098-016-0127-7
Pubmed ID
Authors

Se-Hong Kim, Ju-hye Chung, Sang-Wook Song, Won Sang Jung, Yun-Ah Lee, Ha-Na Kim

Abstract

The deep subcutaneous adipose tissue (dSAT) is closely related to the obesity-associated complications similarly to the characteristics of visceral adipose tissue (VAT). However, the association between dSAT and metabolic syndrome (MS) is unclear. The purpose of our study was to evaluate the association of distinct abdominal adipose tissue with the cardiometabolic risk factors and MS. Abdominal computed tomography (CT) images were obtained in 365 asymptomatic subjects (187 subjects with MS and 178 without MS). The axial images segmented into superficial and deep SAT by manually tracing the fascia superficialis at L4-5 levels. The concentrations of serum inflammatory cytokines and adipokines were also measured. The MS group had significantly lower adiponectin levels but significantly higher levels of resistin, leptin, tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), intercellular adhesion molecule (ICAM), monocyte chemotactic protein-1 (MCP-1), and oxLDL than the control group (p < 0.05). All inflammatory cytokines and adipokines were associated with the sum of VAT and dSAT areas (VDAT) (P for trend < 0.05), but no significant correlation was found between inflammatory cytokines and sSAT. dSAT was significantly associated with MS in both men and women (OR 2.371; p < 0.001) whereas the ORs between sSAT and MS were not significant (p = 0.597). The age-adjusted ORs between VDAT and MS (OR of 8.359 in men and 3.183 in women, p < 0.001) were higher than those of VAT (OR of 7.941 in men and 2.570 in women, p < 0.05) and dSAT (OR of 2.954 in men and 1.856 in women, p < 0.05). We demonstrated that dSAT was associated with increased inflammation and oxidative stress, suggesting that dSAT is an important determinant of MS. Therefore, abdominal subcutaneous fat should be considered as two functionally distinct compartments rather than a single entity.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 58 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 21%
Student > Master 10 17%
Student > Doctoral Student 8 14%
Student > Bachelor 7 12%
Researcher 3 5%
Other 6 10%
Unknown 12 21%
Readers by discipline Count As %
Medicine and Dentistry 18 31%
Agricultural and Biological Sciences 7 12%
Biochemistry, Genetics and Molecular Biology 6 10%
Nursing and Health Professions 3 5%
Immunology and Microbiology 2 3%
Other 8 14%
Unknown 14 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 February 2016.
All research outputs
#20,657,128
of 25,374,917 outputs
Outputs from Diabetology & Metabolic Syndrome
#563
of 796 outputs
Outputs of similar age
#303,730
of 409,928 outputs
Outputs of similar age from Diabetology & Metabolic Syndrome
#9
of 15 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 796 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one is in the 15th percentile – i.e., 15% of its peers scored the same or lower than it.
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