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miR-155 expression level changes might be associated with initial phases of breast cancer pathogenesis and lymph-node metastasis

Overview of attention for article published in Cancer Biomarkers, March 2016
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  • Above-average Attention Score compared to outputs of the same age and source (54th percentile)

Mentioned by

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2 tweeters

Citations

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17 Dimensions

Readers on

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16 Mendeley
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Title
miR-155 expression level changes might be associated with initial phases of breast cancer pathogenesis and lymph-node metastasis
Published in
Cancer Biomarkers, March 2016
DOI 10.3233/cbm-160577
Pubmed ID
Authors

Nina Petrović, Ana Kolaković, Aleksandra Stanković, Silvana Lukić, Ahmad Řami, Maja ivković, Vesna Mandušić

Abstract

Breast carcinoma is heterogeneous disease. Understanding the process of invasion and metastasis and the selection of the therapy for patients with breast carcinomas still remains difficult. MicroRNAs are powerful gene expression regulators. Because of inconsistent findings, we have analyzed potential difference in miR-155 levels in three breast cancer groups. Our goals were to examine miR-155 expression levels in normal tissue, non-invasive and invasive breast carcinomas, and their association with standard clinical and pathological parameters and oncomiR-21, and to investigate the ability of miR-155 to separate invasive breast carcinomas with non-invasive component from pure invasive. In the group of 40 breast tissue samples, relative expression levels of miR-155 were examined with stem-loop quantitative real-time PCR using TaqMan technology. The significant difference among four examined groups of the breast tissue was detected (p = 0.001). In the group of pure invasive tumors, patients with positive nodal status had significantly higher miR-155 levels (p = 0.046). Our results suggest that miR-155 might be involved in breast cancer pathogenesis and in tumor spreading to the lymph nodes, and that it might be used as biomarker for additional stratification of patients with invasive breast carcinomas with non-invasive component.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 16 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 19%
Researcher 2 13%
Student > Bachelor 2 13%
Professor 1 6%
Unspecified 1 6%
Other 0 0%
Unknown 7 44%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 4 25%
Agricultural and Biological Sciences 2 13%
Computer Science 1 6%
Chemical Engineering 1 6%
Medicine and Dentistry 1 6%
Other 0 0%
Unknown 7 44%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 February 2016.
All research outputs
#9,587,104
of 12,480,907 outputs
Outputs from Cancer Biomarkers
#88
of 282 outputs
Outputs of similar age
#173,349
of 270,965 outputs
Outputs of similar age from Cancer Biomarkers
#9
of 24 outputs
Altmetric has tracked 12,480,907 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 282 research outputs from this source. They receive a mean Attention Score of 1.1. This one has gotten more attention than average, scoring higher than 62% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 270,965 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.