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Immunity to Fish Rhabdoviruses

Overview of attention for article published in Viruses (1999-4915), January 2012
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62 Mendeley
Title
Immunity to Fish Rhabdoviruses
Published in
Viruses (1999-4915), January 2012
DOI 10.3390/v4010140
Pubmed ID
Authors

Maureen K. Purcell, Purcell MK, Laing KJ, Winton JR

Abstract

Members of the family Rhabdoviridae are single-stranded RNA viruses and globally important pathogens of wild and cultured fish and thus relatively well studied in their respective hosts or other model systems. Here, we review the protective immune mechanisms that fish mount in response to rhabdovirus infections. Teleost fish possess the principal components of innate and adaptive immunity found in other vertebrates. Neutralizing antibodies are critical for long-term protection from fish rhabdoviruses, but several studies also indicate a role for cell-mediated immunity. Survival of acute rhabdoviral infection is also dependent on innate immunity, particularly the interferon (IFN) system that is rapidly induced in response to infection. Paradoxically, rhabdoviruses are sensitive to the effects of IFN but virulent rhabdoviruses can continue to replicate owing to the abilities of the matrix (M) protein to mediate host-cell shutoff and the non‑virion (NV) protein to subvert programmed cell death and suppress functional IFN. While many basic features of the fish immune response to rhabdovirus infections are becoming better understood, much less is known about how factors in the environment affect the ecology of rhabdovirus infections in natural populations of aquatic animals.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 3%
France 1 2%
Chile 1 2%
Saint Kitts and Nevis 1 2%
Turkey 1 2%
Unknown 56 90%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 15 24%
Researcher 14 23%
Student > Master 8 13%
Unspecified 7 11%
Student > Doctoral Student 6 10%
Other 12 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 25 40%
Unspecified 11 18%
Biochemistry, Genetics and Molecular Biology 7 11%
Medicine and Dentistry 6 10%
Immunology and Microbiology 5 8%
Other 8 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 January 2012.
All research outputs
#10,969,524
of 12,378,406 outputs
Outputs from Viruses (1999-4915)
#1,886
of 2,133 outputs
Outputs of similar age
#193,774
of 227,666 outputs
Outputs of similar age from Viruses (1999-4915)
#52
of 72 outputs
Altmetric has tracked 12,378,406 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,133 research outputs from this source. They receive a mean Attention Score of 4.4. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 227,666 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 72 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.