Title |
Regulatory interactions for iron homeostasis in Aspergillus fumigatus inferred by a Systems Biology approach
|
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Published in |
BMC Systems Biology, January 2012
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DOI | 10.1186/1752-0509-6-6 |
Pubmed ID | |
Authors |
Jörg Linde, Peter Hortschansky, Eugen Fazius, Axel A Brakhage, Reinhard Guthke, Hubertus Haas |
Abstract |
In System Biology, iterations of wet-lab experiments followed by modelling approaches and model-inspired experiments describe a cyclic workflow. This approach is especially useful for the inference of gene regulatory networks based on high-throughput gene expression data. Experiments can verify or falsify the predicted interactions allowing further refinement of the network model. Aspergillus fumigatus is a major human fungal pathogen. One important virulence trait is its ability to gain sufficient amounts of iron during infection process. Even though some regulatory interactions are known, we are still far from a complete understanding of the way iron homeostasis is regulated. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Poland | 1 | 2% |
Germany | 1 | 2% |
Unknown | 47 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 12 | 24% |
Student > Ph. D. Student | 8 | 16% |
Student > Doctoral Student | 5 | 10% |
Student > Bachelor | 5 | 10% |
Professor | 3 | 6% |
Other | 11 | 22% |
Unknown | 5 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 18 | 37% |
Biochemistry, Genetics and Molecular Biology | 12 | 24% |
Computer Science | 4 | 8% |
Engineering | 2 | 4% |
Chemistry | 2 | 4% |
Other | 3 | 6% |
Unknown | 8 | 16% |