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Paraben esters: review of recent studies of endocrine toxicity, absorption, esterase and human exposure, and discussion of potential human health risks

Overview of attention for article published in Journal of Applied Toxicology, July 2008
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#5 of 1,155)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • Good Attention Score compared to outputs of the same age and source (77th percentile)

Mentioned by

news
10 news outlets
policy
1 policy source
twitter
12 tweeters
patent
3 patents
facebook
5 Facebook pages
wikipedia
1 Wikipedia page
video
3 video uploaders

Citations

dimensions_citation
354 Dimensions

Readers on

mendeley
268 Mendeley
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Title
Paraben esters: review of recent studies of endocrine toxicity, absorption, esterase and human exposure, and discussion of potential human health risks
Published in
Journal of Applied Toxicology, July 2008
DOI 10.1002/jat.1358
Pubmed ID
Authors

Philippa D. Darbre, Philip W. Harvey

Abstract

This toxicology update reviews research over the past four years since publication in 2004 of the first measurement of intact esters of p-hydroxybenzoic acid (parabens) in human breast cancer tissues, and the suggestion that their presence in the human body might originate from topical application of bodycare cosmetics. The presence of intact paraben esters in human body tissues has now been confirmed by independent measurements in human urine, and the ability of parabens to penetrate human skin intact without breakdown by esterases and to be absorbed systemically has been demonstrated through studies not only in vitro but also in vivo using healthy human subjects. Using a wide variety of assay systems in vitro and in vivo, the oestrogen agonist properties of parabens together with their common metabolite (p-hydroxybenzoic acid) have been extensively documented, and, in addition, the parabens have now also been shown to possess androgen antagonist activity, to act as inhibitors of sulfotransferase enzymes and to possess genotoxic activity. With the continued use of parabens in the majority of bodycare cosmetics, there is a need to carry out detailed evaluation of the potential for parabens, together with other oestrogenic and genotoxic co-formulants of bodycare cosmetics, to increase female breast cancer incidence, to interfere with male reproductive functions and to influence development of malignant melanoma which has also recently been shown to be influenced by oestrogenic stimulation.

Twitter Demographics

The data shown below were collected from the profiles of 12 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 268 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 2 <1%
India 1 <1%
Norway 1 <1%
Germany 1 <1%
United States 1 <1%
Poland 1 <1%
Unknown 261 97%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 62 23%
Researcher 44 16%
Student > Master 42 16%
Student > Ph. D. Student 32 12%
Other 16 6%
Other 46 17%
Unknown 26 10%
Readers by discipline Count As %
Chemistry 51 19%
Agricultural and Biological Sciences 44 16%
Medicine and Dentistry 35 13%
Environmental Science 21 8%
Pharmacology, Toxicology and Pharmaceutical Science 20 7%
Other 58 22%
Unknown 39 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 105. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 May 2020.
All research outputs
#187,923
of 15,257,997 outputs
Outputs from Journal of Applied Toxicology
#5
of 1,155 outputs
Outputs of similar age
#1,516
of 217,154 outputs
Outputs of similar age from Journal of Applied Toxicology
#2
of 9 outputs
Altmetric has tracked 15,257,997 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,155 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 217,154 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 7 of them.