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Attention Score in Context
| Title |
A Wnt1 regulated Frizzled-1/β-Cateninsignaling pathway as a candidate regulatory circuit controlling mesencephalic dopaminergic neuron-astrocyte crosstalk: Therapeutical relevance for neuron survival and neuroprotection
|
|---|---|
| Published in |
Molecular Neurodegeneration, July 2011
|
| DOI | 10.1186/1750-1326-6-49 |
| Pubmed ID | |
| Authors |
Francesca L'Episcopo, Maria F Serapide, Cataldo Tirolo, Nunzio Testa, Salvatore Caniglia, Maria C Morale, Stefano Pluchino, Bianca Marchetti |
| Abstract |
Dopamine-synthesizing (dopaminergic, DA) neurons in the ventral midbrain (VM) constitute a pivotal neuronal population controlling motor behaviors, cognitive and affective brain functions, which generation critically relies on the activation of Wingless-type MMTV integration site (Wnt)/β-catenin pathway in their progenitors. In Parkinson's disease, DA cell bodies within the substantia nigra pars compacta (SNpc) progressively degenerate, with causes and mechanisms poorly understood. Emerging evidence suggests that Wnt signaling via Frizzled (Fzd) receptors may play a role in different degenerative states, but little is known about Wnt signaling in the adult midbrain. Using in vitro and in vivo model systems of DA degeneration, along with functional studies in both intact and SN lesioned mice, we herein highlight an intrinsic Wnt1/Fzd-1/β-catenin tone critically contributing to the survival and protection of adult midbrain DA neurons. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 122 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | <1% |
| Netherlands | 1 | <1% |
| Argentina | 1 | <1% |
| Unknown | 119 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 32 | 26% |
| Researcher | 21 | 17% |
| Student > Master | 11 | 9% |
| Student > Bachelor | 11 | 9% |
| Other | 7 | 6% |
| Other | 17 | 14% |
| Unknown | 23 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 32 | 26% |
| Neuroscience | 22 | 18% |
| Biochemistry, Genetics and Molecular Biology | 14 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 6% |
| Medicine and Dentistry | 5 | 4% |
| Other | 12 | 10% |
| Unknown | 30 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 February 2012.
All research outputs
#20,699,786
of 23,299,593 outputs
Outputs from Molecular Neurodegeneration
#850
of 864 outputs
Outputs of similar age
#109,202
of 118,074 outputs
Outputs of similar age from Molecular Neurodegeneration
#14
of 14 outputs
Altmetric has tracked 23,299,593 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 864 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.4. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 118,074 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.