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AIDS-associated diarrhea and wasting in Northeast Brazil is associated with subtherapeutic plasma levels of antiretroviral medications and with both bovine and human subtypes of Cryptosporidium parvum.

Overview of attention for article published in Brazilian Journal of Infectious Diseases, February 2003
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Title
AIDS-associated diarrhea and wasting in Northeast Brazil is associated with subtherapeutic plasma levels of antiretroviral medications and with both bovine and human subtypes of Cryptosporidium parvum.
Published in
Brazilian Journal of Infectious Diseases, February 2003
DOI 10.1590/s1413-86702003000100003
Pubmed ID
Authors

Brantley, Richard K, Williams, K Robert, Silva, Terezinha M J, Sistrom, Maria, Thielman, Nathan M, Ward, Honorine, Lima, Aldo A M, Guerrant, Richard L, Richard K. Brantley, K. Robert Williams, Terezinha M.J. Silva, Maria Sistrom, Nathan M. Thielman, Honorine Ward, Aldo A. M. Lima, Richard L. Guerrant

Abstract

Advanced HIV infection is frequently complicated by diarrhea, disruption of bowel structure and function, and malnutrition. Resulting malabsorption of or pharmacokinetic changes in antiretroviral agents might lead to subtherapeutic drug dosing and treatment failure in individual patients, and could require dose adjustment and/or dietary supplements during periods of diarrheal illness. We determined the plasma levels of antiretroviral medications in patients that had already been started on medication by their physicians, in an urban infectious diseases hospital in northeast Brazil. We also obtained blood samples from patients hospitalized for diarrhea or AIDS-associated wasting, and we found reduced stavudine and didanosine levels in comparison with outpatients without diarrhea or wasting who had been treated at the same hospital clinic. There was a predominance of the protozoal pathogens Cryptosporidium and Isospora belli, typical opportunistic pathogens of AIDS-infected humans, in the stool samples of inpatients with diarrhea. We conclude that severe diarrhea and wasting in this population is associated with both protozoal pathogens and subtherapeutic levels of antiretroviral medications.

Mendeley readers

The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 2 5%
United States 1 2%
Unknown 40 93%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 9 21%
Researcher 7 16%
Student > Master 6 14%
Student > Ph. D. Student 5 12%
Student > Doctoral Student 3 7%
Other 11 26%
Unknown 2 5%
Readers by discipline Count As %
Medicine and Dentistry 17 40%
Agricultural and Biological Sciences 9 21%
Immunology and Microbiology 3 7%
Engineering 2 5%
Nursing and Health Professions 2 5%
Other 6 14%
Unknown 4 9%