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Total plasmatic homocysteine and von Willebrand factor in experimental diabetes mellitus.

Overview of attention for article published in Arquivos brasileiros de cardiologia, April 2007
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Title
Total plasmatic homocysteine and von Willebrand factor in experimental diabetes mellitus.
Published in
Arquivos brasileiros de cardiologia, April 2007
DOI 10.1590/s0066-782x2007000400010
Pubmed ID
Authors

Lopes, Renato Delascio, Neves, Lindalva Batista, D'Almeida, Vânia, Conceição, Gleice Margarete de Souza, Gabriel, Alexandre, Renato Delascio Lopes, Lindalva Batista Neves, Vânia D'Almeida, Gleice Margarete de Souza Conceição, Alexandre Gabriel Junior

Abstract

To determine the plasma homocysteine and von Willebrand factor levels as markers of endothelial dysfunction in rats with diabetes mellitus induced by streptozotocin. Thirty-five adult male rats (Rattus norvegicus albinus) (weight between 180-200 g) were randomized into three groups: control group (n=10), which received no drugs or vehicles; sham group (n=10), which received streptozotocin solution; and diabetic group (n=15), which received streptozotocin. Eight weeks after diabetes mellitus induction, the animals were weighed and anesthesized; blood samples were collected from abdominal aorta for plasma total homocysteine, von Willebrand factor and glucose levels. The experimental model was reproducible in 100% of animals. The mean plasma homocysteine levels were: 7.9 micromol/l (control), 8.6 micromol/l (sham) and 6.1 micromol/l (diabetic), with difference among the groups (p<0.01). Multiple comparison analysis among the groups showed that values in the diabetic group were lower than in the sham group (p<0.01). The mean von Willebrand factor values were 0.15 U/l (control), 0.16 U/l (sham) and 0.18 U/l (diabetic), with difference among the groups (p=0.03). The mean value was higher in the diabetic group than in the control group (p<0.05). Correlation between homocysteine and von Willebrand factor was not observed in the diabetic group. Reduced homocysteine levels and increased von Willebrand factor levels were observed in diabetes mellitus induced by streptozotocin; nevertheless, there were no correlations between them and with final glucose levels.

Mendeley readers

The data shown below were compiled from readership statistics for 7 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 7 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 2 29%
Student > Master 1 14%
Student > Ph. D. Student 1 14%
Researcher 1 14%
Professor > Associate Professor 1 14%
Other 1 14%
Readers by discipline Count As %
Medicine and Dentistry 4 57%
Pharmacology, Toxicology and Pharmaceutical Science 2 29%
Biochemistry, Genetics and Molecular Biology 1 14%