Chapter title |
Corticotropin-Releasing Factor (CRF) Neurocircuitry and Neuropharmacology in Alcohol Drinking
|
---|---|
Chapter number | 86 |
Book title |
The Neuropharmacology of Alcohol
|
Published in |
Handbook of experimental pharmacology, January 2018
|
DOI | 10.1007/164_2017_86 |
Pubmed ID | |
Book ISBNs |
978-3-31-996522-2, 978-3-31-996523-9
|
Authors |
Allyson L. Schreiber, Nicholas W. Gilpin, Schreiber, Allyson L., Gilpin, Nicholas W. |
Abstract |
Alcohol use is pervasive in the United States. In the transition from nonhazardous drinking to hazardous drinking and alcohol use disorder, neuroadaptations occur within brain reward and brain stress systems. One brain signaling system that has received much attention in animal models of excessive alcohol drinking and alcohol dependence is corticotropin-releasing factor (CRF). The CRF system is composed of CRF, the urocortins, CRF-binding protein, and two receptors - CRF type 1 and CRF type 2. This review summarizes how acute, binge, and chronic alcohol dysregulates CRF signaling in hypothalamic and extra-hypothalamic brain regions and how this dysregulation may contribute to changes in alcohol reinforcement, excessive alcohol consumption, symptoms of negative affect during withdrawal, and alcohol relapse. In addition, it summarizes clinical work examining CRF type 1 receptor antagonists in humans and discusses why the brain CRF system is still relevant in alcohol research. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 47 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Doctoral Student | 6 | 13% |
Student > Ph. D. Student | 6 | 13% |
Student > Bachelor | 4 | 9% |
Other | 3 | 6% |
Professor | 3 | 6% |
Other | 5 | 11% |
Unknown | 20 | 43% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 10 | 21% |
Biochemistry, Genetics and Molecular Biology | 3 | 6% |
Medicine and Dentistry | 3 | 6% |
Agricultural and Biological Sciences | 2 | 4% |
Psychology | 1 | 2% |
Other | 3 | 6% |
Unknown | 25 | 53% |