@AKoutnik @CSaenzPhD It does seem SGLT2 inhibition increases RAAS levels in the blood in the short term but they return to normal after a few months. https://t.co/Arl5PSoql6
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More on this here: https://t.co/ZD3AjCHZvE
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@eric_weinhandl @mikejohansenmd @NEJM But in spite of my love for number 2, actual data suggest an increase in peripheral renin activity and a tendency toward higher aldo that do not persist for > 6 months under SGLT2i therapy https://t.co/m2LYzNmyKX
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@ChristosArgyrop @kidney_boy @edgarvlermamd @hswapnil @scoca @GeorgeVasquezR2 @aishaikh True, but are not SGLT2i supposed to slightly increase RRAS? For instance, https://t.co/KlTJmj0uKd https://t.co/2rUXxlsx9c