Title |
Decay characteristics of HIV-1-infected compartments during combination therapy
|
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Published in |
Nature, May 1997
|
DOI | 10.1038/387188a0 |
Pubmed ID | |
Authors |
Alan S. Perelson, Paulina Essunger, Yunzhen Cao, Mika Vesanen, Arlene Hurley, Kalle Saksela, Martin Markowitz, David D. Ho |
Abstract |
Analysis of changes in viral load after initiation of treatment with potent antiretroviral agents has provided substantial insight into the dynamics of human immunodeficiency virus type 1 (HIV-1). The concentration of HIV-1 in plasma drops by approximately 99% in the first two weeks of treatment owing to the rapid elimination of free virus with a half-life (t1/2) of < or =6 hours and loss of productively infected cells with a t1/2 of 1.6 days. Here we show that with combination therapy this initial decrease is followed by a slower second-phase decay of plasma viraemia. Detailed mathematical analysis shows that the loss of long-lived infected cells (t1/2 of 1-4 weeks) is a major contributor to the second phase, whereas the activation of latently infected lymphocytes (t1/2 of 0.5-2 weeks) is only a minor source. Based on these decay characteristics, we estimate that 2.3-3.1 years of a completely inhibitory treatment would be required to eliminate HIV-1 from these compartments. To eradicate HIV-1 completely, even longer treatment may be needed because of the possible existence of undetected viral compartments or sanctuary sites. |
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Hungary | 1 | <1% |
Australia | 1 | <1% |
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Other | 3 | <1% |
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Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
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Researcher | 72 | 18% |
Student > Master | 39 | 10% |
Student > Bachelor | 39 | 10% |
Professor | 22 | 6% |
Other | 80 | 20% |
Unknown | 52 | 13% |
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---|---|---|
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Medicine and Dentistry | 70 | 18% |
Biochemistry, Genetics and Molecular Biology | 51 | 13% |
Immunology and Microbiology | 47 | 12% |
Mathematics | 18 | 5% |
Other | 47 | 12% |
Unknown | 68 | 17% |