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Decay characteristics of HIV-1-infected compartments during combination therapy

Overview of attention for article published in Nature, May 1997
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (88th percentile)
  • Good Attention Score compared to outputs of the same age and source (67th percentile)

Mentioned by

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1 policy source
patent
30 patents

Citations

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1606 Dimensions

Readers on

mendeley
398 Mendeley
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1 CiteULike
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1 Connotea
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Title
Decay characteristics of HIV-1-infected compartments during combination therapy
Published in
Nature, May 1997
DOI 10.1038/387188a0
Pubmed ID
Authors

Alan S. Perelson, Paulina Essunger, Yunzhen Cao, Mika Vesanen, Arlene Hurley, Kalle Saksela, Martin Markowitz, David D. Ho

Abstract

Analysis of changes in viral load after initiation of treatment with potent antiretroviral agents has provided substantial insight into the dynamics of human immunodeficiency virus type 1 (HIV-1). The concentration of HIV-1 in plasma drops by approximately 99% in the first two weeks of treatment owing to the rapid elimination of free virus with a half-life (t1/2) of < or =6 hours and loss of productively infected cells with a t1/2 of 1.6 days. Here we show that with combination therapy this initial decrease is followed by a slower second-phase decay of plasma viraemia. Detailed mathematical analysis shows that the loss of long-lived infected cells (t1/2 of 1-4 weeks) is a major contributor to the second phase, whereas the activation of latently infected lymphocytes (t1/2 of 0.5-2 weeks) is only a minor source. Based on these decay characteristics, we estimate that 2.3-3.1 years of a completely inhibitory treatment would be required to eliminate HIV-1 from these compartments. To eradicate HIV-1 completely, even longer treatment may be needed because of the possible existence of undetected viral compartments or sanctuary sites.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 398 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 7 2%
Canada 4 1%
Switzerland 2 <1%
Japan 2 <1%
United Kingdom 2 <1%
Hungary 1 <1%
Australia 1 <1%
Germany 1 <1%
Mexico 1 <1%
Other 3 <1%
Unknown 374 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 94 24%
Researcher 72 18%
Student > Master 39 10%
Student > Bachelor 39 10%
Professor 22 6%
Other 80 20%
Unknown 52 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 97 24%
Medicine and Dentistry 70 18%
Biochemistry, Genetics and Molecular Biology 51 13%
Immunology and Microbiology 47 12%
Mathematics 18 5%
Other 47 12%
Unknown 68 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 October 2021.
All research outputs
#3,282,781
of 22,851,489 outputs
Outputs from Nature
#49,058
of 90,980 outputs
Outputs of similar age
#1,969
of 30,681 outputs
Outputs of similar age from Nature
#64
of 281 outputs
Altmetric has tracked 22,851,489 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 90,980 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 99.4. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 30,681 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 281 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.