↓ Skip to main content

Doublesex and mab-3 related transcription factor 1 ( DMRT1 ) is a sex-specific genetic determinant of childhood-onset asthma and is expressed in testis and macrophages

Overview of attention for article published in The Journal of Allergy and Clinical Immunology, August 2016
Altmetric Badge

About this Attention Score

  • Average Attention Score compared to outputs of the same age
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

twitter
5 tweeters

Citations

dimensions_citation
10 Dimensions

Readers on

mendeley
34 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Doublesex and mab-3 related transcription factor 1 ( DMRT1 ) is a sex-specific genetic determinant of childhood-onset asthma and is expressed in testis and macrophages
Published in
The Journal of Allergy and Clinical Immunology, August 2016
DOI 10.1016/j.jaci.2015.12.1305
Pubmed ID
Authors

Maximilian Schieck, Jan P. Schouten, Sven Michel, Kathrin Suttner, Antoaneta A. Toncheva, Vincent D. Gaertner, Thomas Illig, Simone Lipinski, Andre Franke, Michael Klintschar, Omer Kalayci, Umit M. Sahiner, Esra Birben, Erik Melén, Göran Pershagen, Maxim B. Freidin, Ludmila M. Ogorodova, Raquel Granell, John Henderson, Bert Brunekreef, Henriëtte A. Smit, Christian Vogelberg, Andrea von Berg, Albrecht Bufe, Andrea Heinzmann, Otto Laub, Ernst Rietschel, Burkhard Simma, Jon Genuneit, Danny Jonigk, Dirkje S. Postma, Gerard H. Koppelman, Judith M. Vonk, Wim Timens, H. Marike Boezen, Michael Kabesch

Abstract

Asthma is a disease affecting more boys than girls in childhood and more women than men in adulthood. The mechanisms behind these sex-specific differences are not yet understood. We analyzed whether and how genetic factors contribute to sex-specific predisposition to childhood-onset asthma. Interactions between sex and polymorphisms on childhood asthma risk were evaluated in the Multicentre Asthma Genetics in Childhood Study (MAGICS)/Phase II International Study of Asthma and Allergies in Childhood (ISAAC II) population on a genome-wide level, and findings were validated in independent populations. Genetic fine mapping of sex-specific asthma association signals was performed, and putatively causal polymorphisms were characterized in vitro by using electrophoretic mobility shift and luciferase activity assays. Gene and protein expression of the identified gene doublesex and mab-3 related transcription factor 1 (DMRT1) were measured in different human tissues by using quantitative real-time PCR and immunohistochemistry. Polymorphisms in the testis-associated gene DMRT1 displayed interactions with sex on asthma status in a population of primarily clinically defined asthmatic children and nonasthmatic control subjects (lowest P = 5.21 × 10(-6)). Replication of this interaction was successful in 2 childhood populations clinically assessed for asthma but showed heterogeneous results in other population-based samples. Polymorphism rs3812523 located in the putative DMRT1 promoter was associated with allele-specific changes in transcription factor binding and promoter activity in vitro. DMRT1 expression was observed not only in the testis but also in lung macrophages. DMRT1 might influence sex-specific patterns of childhood asthma, and its expression in testis tissue and lung macrophages suggests a potential involvement in hormone or immune cell regulation.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 3%
Sweden 1 3%
Unknown 32 94%

Demographic breakdown

Readers by professional status Count As %
Unspecified 6 18%
Researcher 6 18%
Student > Doctoral Student 5 15%
Student > Bachelor 4 12%
Other 3 9%
Other 10 29%
Readers by discipline Count As %
Unspecified 10 29%
Medicine and Dentistry 8 24%
Biochemistry, Genetics and Molecular Biology 7 21%
Agricultural and Biological Sciences 4 12%
Psychology 2 6%
Other 3 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 June 2017.
All research outputs
#7,008,829
of 12,194,389 outputs
Outputs from The Journal of Allergy and Clinical Immunology
#5,908
of 7,408 outputs
Outputs of similar age
#136,577
of 292,686 outputs
Outputs of similar age from The Journal of Allergy and Clinical Immunology
#187
of 302 outputs
Altmetric has tracked 12,194,389 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,408 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.9. This one is in the 18th percentile – i.e., 18% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 292,686 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
We're also able to compare this research output to 302 others from the same source and published within six weeks on either side of this one. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.