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X Demographics
Mendeley readers
Attention Score in Context
| Title |
High-throughput proteomics reveal alarmins as amplifiers of tissue pathology and inflammation after spinal cord injury
|
|---|---|
| Published in |
Scientific Reports, February 2016
|
| DOI | 10.1038/srep21607 |
| Pubmed ID | |
| Authors |
Athanasios Didangelos, Michele Puglia, Michaela Iberl, Candela Sanchez-Bellot, Bernd Roschitzki, Elizabeth J. Bradbury |
| Abstract |
Spinal cord injury is characterized by acute cellular and axonal damage followed by aggressive inflammation and pathological tissue remodelling. The biological mediators underlying these processes are still largely unknown. Here we apply an innovative proteomics approach targeting the enriched extracellular proteome after spinal cord injury for the first time. Proteomics revealed multiple matrix proteins not previously associated with injured spinal tissue, including small proteoglycans involved in cell-matrix adhesion and collagen fibrillogenesis. Network analysis of transcriptomics and proteomics datasets uncovered persistent overexpression of extracellular alarmins that can trigger inflammation via pattern recognition receptors. In mechanistic experiments, inhibition of toll-like receptor-4 (TLR4) and the receptor for advanced glycation end-products (RAGE) revealed the involvement of alarmins in inflammatory gene expression, which was found to be dominated by IL1 and NFκΒ signalling. Extracellular high-mobility group box-1 (HMGB1) was identified as the likely endogenous regulator of IL1 expression after injury. These data reveal a novel tissue remodelling signature and identify endogenous alarmins as amplifiers of the inflammatory response that promotes tissue pathology and impedes neuronal repair after spinal cord injury. |
X Demographics
The data shown below were collected from the profiles of 13 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 4 | 31% |
| Germany | 2 | 15% |
| Japan | 1 | 8% |
| United States | 1 | 8% |
| Canada | 1 | 8% |
| Unknown | 4 | 31% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 9 | 69% |
| Scientists | 2 | 15% |
| Practitioners (doctors, other healthcare professionals) | 1 | 8% |
| Science communicators (journalists, bloggers, editors) | 1 | 8% |
Mendeley readers
The data shown below were compiled from readership statistics for 114 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Chile | 1 | <1% |
| Germany | 1 | <1% |
| Unknown | 112 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 20 | 18% |
| Student > Master | 18 | 16% |
| Researcher | 15 | 13% |
| Student > Bachelor | 9 | 8% |
| Student > Doctoral Student | 9 | 8% |
| Other | 23 | 20% |
| Unknown | 20 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 31 | 27% |
| Agricultural and Biological Sciences | 19 | 17% |
| Biochemistry, Genetics and Molecular Biology | 15 | 13% |
| Medicine and Dentistry | 12 | 11% |
| Materials Science | 3 | 3% |
| Other | 12 | 11% |
| Unknown | 22 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 March 2016.
All research outputs
#3,103,981
of 22,851,489 outputs
Outputs from Scientific Reports
#26,479
of 123,393 outputs
Outputs of similar age
#51,339
of 298,740 outputs
Outputs of similar age from Scientific Reports
#780
of 3,432 outputs
Altmetric has tracked 22,851,489 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 123,393 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.2. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 298,740 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 3,432 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 77% of its contemporaries.