Chapter 1 Mechanisms of Drug-Induced Cholestasis

Chapter 2 LC-MS/MS Analysis of Bile Acids in In Vitro Samples

Chapter 3 Pipe-3D: A Pipeline Based on Immunofluorescence, 3D Confocal Imaging, Reconstructions, and Morphometry for Biliary Network Analysis in Cholestasis

Chapter 4 Vesicle- and Hepatocyte-Based Assays for Identification of Drug Candidates Inhibiting BSEP Function

Chapter 5 The C-DILI™ Assay: An Integrated In Vitro Approach to Predict Cholestatic Hepatotoxicity

Chapter 6 In Vivo Measurement of Hepatic Drug Transporter Inhibition with Radiolabeled Bile Acids

Chapter 7 Measuring the Impact of Bile Acids on the Membrane Order of Primary Hepatocytes and Isolated Mitochondria by Fluorescence Imaging and Spectroscopy

Chapter 8 The Role and Study of Mitochondrial Impairment and Oxidative Stress in Cholestasis

Chapter 9 Measuring Apoptosis and Necrosis in Cholestatic Liver Injury

Chapter 10 Necrosome Formation and Necroptosis in Experimental Cholestasis

Chapter 12 Transcriptomic Analysis of Cholestatic Compounds In Vitro

Chapter 13 System Microscopy of Stress Response Pathways in Cholestasis Research

Chapter 14 Mouse Models for Diseases in the Cholangiocyte Lineage

Chapter 15 Common Bile Duct Ligation as Model for Secondary Biliary Cirrhosis

Chapter 16 3,5-Diethoxycarbonyl-1,4-Dihydrocollidine Diet: A Rodent Model in Cholestasis Research

Chapter 17 A Rotavirus-Induced Mouse Model to Study Biliary Atresia and Neonatal Cholestasis

Chapter 18 Zebrafish as a Model to Study Cholestatic Liver Diseases

Chapter 19 Setup and Use of HepaRG Cells in Cholestasis Research

Chapter 20 Organotypic 3D HepaRG Liver Model for Assessment of Drug-Induced Cholestasis

Chapter 21 Establishment of Sandwich Cultures of Primary Human Hepatocytes

Chapter 22 Detection of Drug-Induced Cholestasis Potential in Sandwich-Cultured Human Hepatocytes

Chapter 23 Ex Vivo Model in Cholestasis Research

Chapter 24 Patient-Derived Organoids from Human Bile: An In Vitro Method to Study Cholangiopathies

Chapter 25 Use of Biliary Organoids in Cholestasis Research

Chapter 26 In Silico Approaches to Predict Drug-Transporter Interaction Profiles: Data Mining, Model Generation, and Link to Cholestasis