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Association of Interleukin-17 polymorphism (-197G/A) in chronic and localized aggressive periodontitis

Overview of attention for article published in Brazilian Oral Research, January 2016
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Title
Association of Interleukin-17 polymorphism (-197G/A) in chronic and localized aggressive periodontitis
Published in
Brazilian Oral Research, January 2016
DOI 10.1590/1807-3107bor-2016.vol30.0026
Pubmed ID
Authors

CHAUDHARI, Harshal Liladhar, WARAD, Shivaraj, ASHOK, Nipun, BAROUDI, Kusai, TARAKJI, Bassel, CHAUDHARI, Harshal Liladhar, WARAD, Shivaraj, ASHOK, Nipun, BAROUDI, Kusai, TARAKJI, Bassel

Abstract

Interleukin 17(IL-17) is a pro-inflammatory cytokine produced mainly by Th17 cells. The present study was undertaken to investigate a possible association between IL-17 A genetic polymorphism at (-197A/G) and susceptibility to chronic and localized aggressive periodontitis (LAgP) in an Indian population. The study was carried out on 105 subjects, which included 35 LAgP patients, 35 chronic periodontitis patients and 35 healthy controls. Blood samples were drawn from the subjects and analyzed for IL-17 genetic polymorphism at (-197A/G), by using the polymerase chain reaction-restriction fragment length polymorphism method. A statistically significant difference was seen in the genotype distribution among chronic periodontitis patients, LAgP patients and healthy subjects. There was a significant difference in the distribution of alleles among chronic periodontitis patients, LAgP patients and healthy subjects. The odds ratio for A allele versus G allele was 5.1 between chronic periodontitis patients and healthy controls, and 5.1 between LAgp patients and healthy controls. Our study concluded that IL-17 A gene polymorphism at (-197A/G) is linked to chronic periodontitis and LAgP in Indian population. The presence of allele A in the IL-17 gene polymorphism (-197A/G) can be considered a risk factor for chronic periodontitis and LAgP.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 40 100%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 9 23%
Student > Ph. D. Student 6 15%
Researcher 5 13%
Student > Doctoral Student 5 13%
Student > Master 5 13%
Other 7 18%
Unknown 3 8%
Readers by discipline Count As %
Medicine and Dentistry 22 55%
Biochemistry, Genetics and Molecular Biology 5 13%
Engineering 3 8%
Agricultural and Biological Sciences 3 8%
Nursing and Health Professions 1 3%
Other 2 5%
Unknown 4 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 February 2016.
All research outputs
#6,288,871
of 7,282,696 outputs
Outputs from Brazilian Oral Research
#88
of 110 outputs
Outputs of similar age
#237,571
of 282,564 outputs
Outputs of similar age from Brazilian Oral Research
#5
of 7 outputs
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So far Altmetric has tracked 110 research outputs from this source. They receive a mean Attention Score of 1.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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