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Formin Is Associated with Left-Right Asymmetry in the Pond Snail and the Frog

Overview of attention for article published in Current Biology, March 2016
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (95th percentile)

Citations

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74 Dimensions

Readers on

mendeley
171 Mendeley
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2 CiteULike
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Title
Formin Is Associated with Left-Right Asymmetry in the Pond Snail and the Frog
Published in
Current Biology, March 2016
DOI 10.1016/j.cub.2015.12.071
Pubmed ID
Authors

Angus Davison, Gary S. McDowell, Jennifer M. Holden, Harriet F. Johnson, Georgios D. Koutsovoulos, M. Maureen Liu, Paco Hulpiau, Frans Van Roy, Christopher M. Wade, Ruby Banerjee, Fengtang Yang, Satoshi Chiba, John W. Davey, Daniel J. Jackson, Michael Levin, Mark L. Blaxter

Abstract

While components of the pathway that establishes left-right asymmetry have been identified in diverse animals, from vertebrates to flies, it is striking that the genes involved in the first symmetry-breaking step remain wholly unknown in the most obviously chiral animals, the gastropod snails. Previously, research on snails was used to show that left-right signaling of Nodal, downstream of symmetry breaking, may be an ancestral feature of the Bilateria [1, 2]. Here, we report that a disabling mutation in one copy of a tandemly duplicated, diaphanous-related formin is perfectly associated with symmetry breaking in the pond snail. This is supported by the observation that an anti-formin drug treatment converts dextral snail embryos to a sinistral phenocopy, and in frogs, drug inhibition or overexpression by microinjection of formin has a chirality-randomizing effect in early (pre-cilia) embryos. Contrary to expectations based on existing models [3-5], we discovered asymmetric gene expression in 2- and 4-cell snail embryos, preceding morphological asymmetry. As the formin-actin filament has been shown to be part of an asymmetry-breaking switch in vitro [6, 7], together these results are consistent with the view that animals with diverse body plans may derive their asymmetries from the same intracellular chiral elements [8].

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 171 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 1%
Japan 2 1%
United Kingdom 2 1%
Finland 1 <1%
Argentina 1 <1%
Belgium 1 <1%
Norway 1 <1%
Netherlands 1 <1%
Unknown 160 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 47 27%
Student > Ph. D. Student 32 19%
Student > Bachelor 28 16%
Student > Master 13 8%
Professor > Associate Professor 10 6%
Other 29 17%
Unknown 12 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 73 43%
Biochemistry, Genetics and Molecular Biology 53 31%
Neuroscience 5 3%
Medicine and Dentistry 5 3%
Physics and Astronomy 4 2%
Other 19 11%
Unknown 12 7%

Attention Score in Context

This research output has an Altmetric Attention Score of 540. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 January 2020.
All research outputs
#15,817
of 14,354,109 outputs
Outputs from Current Biology
#159
of 10,424 outputs
Outputs of similar age
#524
of 267,357 outputs
Outputs of similar age from Current Biology
#8
of 194 outputs
Altmetric has tracked 14,354,109 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 10,424 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 42.8. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,357 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 194 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.