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mTOR, a New Potential Target for Chronic Pain and Opioid-Induced Tolerance and Hyperalgesia

Overview of attention for article published in Molecular Pain, May 2015
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1 Redditor

Citations

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38 Dimensions

Readers on

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51 Mendeley
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Title
mTOR, a New Potential Target for Chronic Pain and Opioid-Induced Tolerance and Hyperalgesia
Published in
Molecular Pain, May 2015
DOI 10.1186/s12990-015-0030-5
Pubmed ID
Authors

Brianna Marie Lutz, Sam Nia, Ming Xiong, Yuan-Xiang Tao, Alex Bekker

Abstract

Chronic pain is a major public health problem with limited treatment options. Opioids remain a routine treatment for chronic pain, but extended exposure to opioid therapy can produce opioid tolerance and hyperalgesia. Although the mechanisms underlying chronic pain, opioid-induced tolerance, and opioid-induced hyperalgesia remain to be uncovered, mammalian target of rapamycin (mTOR) is involved in these disorders. The mTOR complex 1 and its triggered protein translation are required for the initiation and maintenance of chronic pain (including cancer pain) and opioid-induced tolerance/hyperalgesia. Given that mTOR inhibitors are FDA-approved drugs and an mTOR inhibitor is approved for treatment of several cancers, these findings suggest that mTOR inhibitors will likely have multiple clinical benefits, including anticancer, antinociception/anti-cancer pain, and antitolerance/hyperalgesia. This paper compares the role of mTOR complex 1 in chronic pain, opioid-induced tolerance, and opioid-induced hyperalgesia.

Mendeley readers

The data shown below were compiled from readership statistics for 51 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Brazil 1 2%
Unknown 49 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 20%
Researcher 7 14%
Student > Master 7 14%
Student > Bachelor 7 14%
Student > Doctoral Student 6 12%
Other 8 16%
Unknown 6 12%
Readers by discipline Count As %
Medicine and Dentistry 13 25%
Agricultural and Biological Sciences 10 20%
Neuroscience 8 16%
Biochemistry, Genetics and Molecular Biology 4 8%
Psychology 3 6%
Other 6 12%
Unknown 7 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 February 2016.
All research outputs
#11,167,460
of 12,552,259 outputs
Outputs from Molecular Pain
#405
of 464 outputs
Outputs of similar age
#223,626
of 267,166 outputs
Outputs of similar age from Molecular Pain
#9
of 9 outputs
Altmetric has tracked 12,552,259 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 464 research outputs from this source. They receive a mean Attention Score of 3.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,166 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one.