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High-fructose and high-fat diet-induced disorders in rats: impact on diabetes risk, hepatic and vascular complications

Overview of attention for article published in Nutrition & Metabolism, February 2016
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (57th percentile)

Mentioned by

3 tweeters
1 Facebook page
1 video uploader


114 Dimensions

Readers on

272 Mendeley
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High-fructose and high-fat diet-induced disorders in rats: impact on diabetes risk, hepatic and vascular complications
Published in
Nutrition & Metabolism, February 2016
DOI 10.1186/s12986-016-0074-1
Pubmed ID

Iona Lozano, Remmelt Van der Werf, William Bietiger, Elodie Seyfritz, Claude Peronet, Michel Pinget, Nathalie Jeandidier, Elisa Maillard, Eric Marchioni, Séverine Sigrist, Stéphanie Dal


As a result of the increased consumption of sugar-rich and fatty-products, and the increase in preference for such products, metabolic disorders are becoming more common at a younger age. Fructose is particularly used in prepared foods and carbonated beverages. We investigated the impact of regular consumption of fructose, in combination or not with fatty food, on the onset of metabolic syndrome and type 2 diabetes (T2D). We evaluated the metabolic, oxidative, and functional effects on the liver and blood vessels, both related to diabetes complications. High-fat diet (HFD), high-fructose beverages (HF) or both (HFHF) were compared to rats fed with normal diet (ND) for 8 months to induce T2D and its metabolic, oxidative, and functional complications. Metabolic control was determined by measuring body weight, fasting blood glucose, C-peptide, HOMA2-IR, leptin, and cholesterol; oxidative parameters were studied by lipid peroxidation and total antioxidant capacity in plasma and the use of ROS labelling on tissue. Histological analysis was performed on the liver and endothelial function was performed in main mesenteric artery using organ-baths. After 2 months, HFHF and HFD increased body weight, leptin, HOMA2-IR associated to steatosis, oxidative stress in plasma and tissues, whereas HF had only a transient increase of leptin and c-peptide. Only HFHF induced fasting hyperglycaemia after 6 months and persistent hyperinsulinaemia and fasting hyperglycaemia with complicated steatosis (inflammation and fibrosis) after 8 months. HFHF and HFD induced endothelial dysfunction at 8 months of diet. Six months, high fat and high carbohydrate induced T2D with widespread tissues effects. We demonstrated the role of oxidative stress in pathogenesis as well as in complications (hepatic and vascular), reinforcing interest in the use of antioxidants in the prevention and treatment of metabolic diseases, including T2D.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 272 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Unknown 271 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 48 18%
Student > Master 48 18%
Student > Ph. D. Student 47 17%
Student > Postgraduate 20 7%
Researcher 19 7%
Other 40 15%
Unknown 50 18%
Readers by discipline Count As %
Medicine and Dentistry 50 18%
Biochemistry, Genetics and Molecular Biology 47 17%
Agricultural and Biological Sciences 44 16%
Pharmacology, Toxicology and Pharmaceutical Science 20 7%
Nursing and Health Professions 17 6%
Other 34 13%
Unknown 60 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 April 2018.
All research outputs
of 12,860,000 outputs
Outputs from Nutrition & Metabolism
of 650 outputs
Outputs of similar age
of 266,117 outputs
Outputs of similar age from Nutrition & Metabolism
of 1 outputs
Altmetric has tracked 12,860,000 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 650 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 21.2. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,117 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them