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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The kinase CK1ɛ controls the antiviral immune response by phosphorylating the signaling adaptor TRAF3
|
|---|---|
| Published in |
Nature Immunology, February 2016
|
| DOI | 10.1038/ni.3395 |
| Pubmed ID | |
| Authors |
Yilong Zhou, Chenxi He, Dapeng Yan, Feng Liu, Haipeng Liu, Jianxia Chen, Ting Cao, Mianyong Zuo, Peng Wang, Yan Ge, Haojie Lu, Qinghe Tong, Chengfeng Qin, Yongqiang Deng, Baoxue Ge |
| Abstract |
The signaling adaptor TRAF3 is a highly versatile regulator of both innate immunity and adaptive immunity, but how its phosphorylation is regulated is still unknown. Here we report that deficiency in or inhibition of the conserved serine-threonine kinase CK1ɛ suppressed the production of type I interferon in response to viral infection. CK1ɛ interacted with and phosphorylated TRAF3 at Ser349, which thereby promoted the Lys63 (K63)-linked ubiquitination of TRAF3 and subsequent recruitment of the kinase TBK1 to TRAF3. Consequently, CK1ɛ-deficient mice were more susceptible to viral infection. Our findings establish CK1ɛ as a regulator of antiviral innate immune responses and indicate a novel mechanism of immunoregulation that involves CK1ɛ-mediated phosphorylation of TRAF3. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 2 | 22% |
| United States | 2 | 22% |
| United Kingdom | 1 | 11% |
| France | 1 | 11% |
| Unknown | 3 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 67% |
| Scientists | 2 | 22% |
| Science communicators (journalists, bloggers, editors) | 1 | 11% |
Mendeley readers
The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 37 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 8 | 22% |
| Researcher | 6 | 16% |
| Student > Ph. D. Student | 5 | 14% |
| Student > Doctoral Student | 3 | 8% |
| Other | 2 | 5% |
| Other | 3 | 8% |
| Unknown | 10 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 8 | 22% |
| Biochemistry, Genetics and Molecular Biology | 7 | 19% |
| Immunology and Microbiology | 6 | 16% |
| Medicine and Dentistry | 2 | 5% |
| Psychology | 1 | 3% |
| Other | 2 | 5% |
| Unknown | 11 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 October 2018.
All research outputs
#6,159,923
of 22,852,911 outputs
Outputs from Nature Immunology
#2,275
of 3,810 outputs
Outputs of similar age
#85,474
of 297,592 outputs
Outputs of similar age from Nature Immunology
#46
of 69 outputs
Altmetric has tracked 22,852,911 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 3,810 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 31.4. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 297,592 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 69 others from the same source and published within six weeks on either side of this one. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.