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Regulation of fibroblast growth factor 15/19 and 21 on metabolism: in the fed or fasted state

Overview of attention for article published in Journal of Translational Medicine, March 2016
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Title
Regulation of fibroblast growth factor 15/19 and 21 on metabolism: in the fed or fasted state
Published in
Journal of Translational Medicine, March 2016
DOI 10.1186/s12967-016-0821-0
Pubmed ID
Authors

Dandan Guan, Lidan Zhao, Daiwen Chen, Bing Yu, Jie Yu

Abstract

Fibroblast growth factor (FGF) 15/19 and FGF21 are two atypical members of FGF19 subfamily that function as hormones. Exogenous FGF15/19 and FGF21 have pharmacological effects, and endogenous FGF15/19 and FGF21 play vital roles in the maintenance of energy homeostasis. Recent reports have expanded the effects of FGF15/19 and FGF21 on carbohydrate and lipid metabolism. However, the regulations of FGF15/19 and FGF21 on metabolism are different. FGF15/19 is mainly secreted from the small intestine in response to feeding, and FGF21 is secreted from the liver in response to extended fasting and from the liver and adipose tissue in response to feeding. In this work, we reviewed the regulatory effects of FGF15/19 and FGF21 on metabolism in the fast and fed states. This information may provide some insight into the metabolic regulation of FGF15/19 and FGF21 in different physiological condition.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Chile 1 2%
Unknown 52 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 11 21%
Student > Ph. D. Student 10 19%
Student > Bachelor 5 9%
Other 4 8%
Lecturer 3 6%
Other 6 11%
Unknown 14 26%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 15 28%
Medicine and Dentistry 7 13%
Agricultural and Biological Sciences 6 11%
Sports and Recreations 4 8%
Nursing and Health Professions 2 4%
Other 5 9%
Unknown 14 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 March 2016.
All research outputs
#15,362,070
of 22,852,911 outputs
Outputs from Journal of Translational Medicine
#2,236
of 3,999 outputs
Outputs of similar age
#177,096
of 298,399 outputs
Outputs of similar age from Journal of Translational Medicine
#40
of 74 outputs
Altmetric has tracked 22,852,911 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,999 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.5. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 298,399 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 74 others from the same source and published within six weeks on either side of this one. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.