Title |
Nucleoplasmic Lamin A/C and Polycomb group of proteins: An evolutionarily conserved interplay
|
---|---|
Published in |
Nucleus, March 2016
|
DOI | 10.1080/19491034.2016.1157675 |
Pubmed ID | |
Authors |
F. Marullo, E. Cesarini, L. Antonelli, F. Gregoretti, G. Oliva, C. Lanzuolo |
Abstract |
Nuclear lamins are the main components of the nuclear lamina at the nuclear periphery, providing mechanical support to the nucleus. However, recent findings suggest that lamins also reside in the nuclear interior, as a distinct and dynamic pool with critical roles in transcriptional regulation. In our work we found a functional and evolutionary conserved crosstalk between LaminA/C and the Polycomb group (PcG) of proteins, this being required for the maintenance of the PcG repressive functions. Indeed, Lamin A/C knock-down causes PcG foci dispersion and defects in PcG-mediated higher order structures, thereby leading to impaired PcG mediated transcriptional repression. By using ad-hoc algorithms for image analysis and PLA approaches we hereby show that PcG proteins are preferentially located in the nuclear interior where they interact with nucleoplasmic LaminA/C. Taken together, our findings suggest that nuclear components, such as Lamin A/C, functionally interact with epigenetic factors to ensure the correct transcriptional program maintenance. |
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Italy | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 100% |
Mendeley readers
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Japan | 1 | 2% |
Unknown | 59 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 12 | 20% |
Researcher | 12 | 20% |
Student > Master | 9 | 15% |
Student > Bachelor | 4 | 7% |
Student > Doctoral Student | 3 | 5% |
Other | 10 | 17% |
Unknown | 10 | 17% |
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Neuroscience | 4 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Unspecified | 1 | 2% |
Other | 4 | 7% |
Unknown | 11 | 18% |