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In VitroApproach for Identification of the Most Effective Agents for Antimicrobial Lock Therapy in the Treatment of Intravascular Catheter-Related Infections Caused by Staphylococcus aureus

Overview of attention for article published in Antimicrobial Agents and Chemotherapy, February 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (86th percentile)
  • Good Attention Score compared to outputs of the same age and source (74th percentile)

Mentioned by

news
1 news outlet
twitter
4 tweeters

Citations

dimensions_citation
27 Dimensions

Readers on

mendeley
42 Mendeley
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Title
In VitroApproach for Identification of the Most Effective Agents for Antimicrobial Lock Therapy in the Treatment of Intravascular Catheter-Related Infections Caused by Staphylococcus aureus
Published in
Antimicrobial Agents and Chemotherapy, February 2016
DOI 10.1128/aac.02885-15
Pubmed ID
Authors

S. Hogan, M. Zapotoczna, N. T. Stevens, H. Humphreys, J. P. O'Gara, E. O'Neill

Abstract

Infections of intravascular catheters by Staphylococcus aureus is a significant risk factor within the healthcare setting. To treat these infections and attempt salvage of an intravascular catheter, antimicrobial lock solutions (ALSs) are being increasingly used. However, the most effective ALSs against these biofilm mediated infections has yet to be determined and clinical practice varies greatly. The purpose of this study was to evaluate and compare the efficacy of antibiotics and antiseptics in current clinical use against biofilms produced by reference and clinical isolates of S. aureus. Static and flow biofilm assays were developed using newly described in vivo relevant conditions, to examine the effect of each agent on S. aureus within the biofilm matrix. The antibiotics daptomycin, tigecycline and rifampicin and the antiseptics ethanol and Turalock(TM) inactivated established S. aureus biofilm while other commonly used anti-staphylococcal antibiotics and antiseptic agents were less effective. These findings were confirmed by live/dead staining of S. aureus biofilms formed and treated within a flow cell model. The results from this study demonstrate the most effective clinically used agents and their concentrations which should be used within an ALS to treat S. aureus mediated intravascular catheter related infections.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Denmark 1 2%
Unknown 41 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 21%
Student > Master 8 19%
Student > Ph. D. Student 7 17%
Student > Bachelor 5 12%
Other 3 7%
Other 9 21%
Unknown 1 2%
Readers by discipline Count As %
Medicine and Dentistry 11 26%
Biochemistry, Genetics and Molecular Biology 8 19%
Agricultural and Biological Sciences 7 17%
Immunology and Microbiology 6 14%
Chemical Engineering 1 2%
Other 5 12%
Unknown 4 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 May 2016.
All research outputs
#1,449,070
of 14,123,042 outputs
Outputs from Antimicrobial Agents and Chemotherapy
#1,119
of 11,987 outputs
Outputs of similar age
#36,186
of 267,438 outputs
Outputs of similar age from Antimicrobial Agents and Chemotherapy
#66
of 255 outputs
Altmetric has tracked 14,123,042 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,987 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,438 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 255 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.