Acquisition of a CD19-negative myeloid phenotype allows immune escape of MLL-rearranged B-ALL from CD19 CAR-T-cell therapy

RT @leowanglab: @JohnSVanArnam @pillai_vinodh @matthewoberley link to @matthewoberley's (awesome) ZNF384 paper here: https://t.co/bjlAXY3p…

@JohnSVanArnam @pillai_vinodh @matthewoberley link to @matthewoberley's (awesome) ZNF384 paper here: https://t.co/bjlAXY3phL; Rebecca Gardner's (also awesome) KMT2A paper here: https://t.co/y8fL2xCCo3.

@t_e_knight In their previous paper https://t.co/paPRvpLsFH authors demonstrated in 2/7 patient with MLL B-ALL post CD19 CAR T developed AML clonally related to their B-ALL. In current paper patient #4 (see below) also had MLL B cell ALL: in MLL ALL ris

RT @DrMiguelPerales: Acquisition of a CD19-negative myeloid phenotype allows immune escape of MLL-rearranged B-ALL from CD19 CAR-T-cell the…