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A genome-wide association scan in admixed Latin Americans identifies loci influencing facial and scalp hair features

Overview of attention for article published in Nature Communications, March 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#3 of 12,332)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

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mendeley
157 Mendeley
citeulike
3 CiteULike
Title
A genome-wide association scan in admixed Latin Americans identifies loci influencing facial and scalp hair features
Published in
Nature Communications, March 2016
DOI 10.1038/ncomms10815
Pubmed ID
Authors

Adhikari, Kaustubh, Fontanil, Tania, Cal, Santiago, Mendoza-Revilla, Javier, Fuentes-Guajardo, Macarena, Chacón-Duque, Juan-Camilo, Al-Saadi, Farah, Johansson, Jeanette A, Quinto-Sanchez, Mirsha, Acuña-Alonzo, Victor, Jaramillo, Claudia, Arias, William, Barquera Lozano, Rodrigo, Macín Pérez, Gastón, Gómez-Valdés, Jorge, Villamil-Ramírez, Hugo, Hunemeier, Tábita, Ramallo, Virginia, Silva de Cerqueira, Caio C, Hurtado, Malena, Villegas, Valeria, Granja, Vanessa, Gallo, Carla, Poletti, Giovanni, Schuler-Faccini, Lavinia, Salzano, Francisco M, Bortolini, Maria-Cátira, Canizales-Quinteros, Samuel, Rothhammer, Francisco, Bedoya, Gabriel, Gonzalez-José, Rolando, Headon, Denis, López-Otín, Carlos, Tobin, Desmond J, Balding, David, Ruiz-Linares, Andrés, Kaustubh Adhikari, Tania Fontanil, Santiago Cal, Javier Mendoza-Revilla, Macarena Fuentes-Guajardo, Juan-Camilo Chacón-Duque, Farah Al-Saadi, Jeanette A. Johansson, Mirsha Quinto-Sanchez, Victor Acuña-Alonzo, Claudia Jaramillo, William Arias, Rodrigo Barquera Lozano, Gastón Macín Pérez, Jorge Gómez-Valdés, Hugo Villamil-Ramírez, Tábita Hunemeier, Virginia Ramallo, Caio C. Silva de Cerqueira, Malena Hurtado, Valeria Villegas, Vanessa Granja, Carla Gallo, Giovanni Poletti, Lavinia Schuler-Faccini, Francisco M. Salzano, Maria-Cátira Bortolini, Samuel Canizales-Quinteros, Francisco Rothhammer, Gabriel Bedoya, Rolando Gonzalez-José, Denis Headon, Carlos López-Otín, Desmond J. Tobin, David Balding, Andrés Ruiz-Linares, Jeanette Johansson, Adhikari K, Fontanil T, Cal S, Mendoza-Revilla J, Fuentes-Guajardo M, Chacón-Duque JC, Al-Saadi F, Johansson JA, Quinto-Sanchez M, Acuña-Alonzo V, Jaramillo C, Arias W, Barquera Lozano R, Macín Pérez G, Gómez-Valdés J, Villamil-Ramírez H, Hunemeier T, Ramallo V, Silva de Cerqueira CC, Hurtado M, Villegas V, Granja V, Gallo C, Poletti G, Schuler-Faccini L, Salzano FM, Bortolini MC, Canizales-Quinteros S, Rothhammer F, Bedoya G, Gonzalez-José R, Headon D, López-Otín C, Tobin DJ, Balding D, Ruiz-Linares A

Abstract

We report a genome-wide association scan in over 6,000 Latin Americans for features of scalp hair (shape, colour, greying, balding) and facial hair (beard thickness, monobrow, eyebrow thickness). We found 18 signals of association reaching genome-wide significance (P values 5 × 10(-8) to 3 × 10(-119)), including 10 novel associations. These include novel loci for scalp hair shape and balding, and the first reported loci for hair greying, monobrow, eyebrow and beard thickness. A newly identified locus influencing hair shape includes a Q30R substitution in the Protease Serine S1 family member 53 (PRSS53). We demonstrate that this enzyme is highly expressed in the hair follicle, especially the inner root sheath, and that the Q30R substitution affects enzyme processing and secretion. The genome regions associated with hair features are enriched for signals of selection, consistent with proposals regarding the evolution of human hair.

Twitter Demographics

The data shown below were collected from the profiles of 257 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 157 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 5 3%
Brazil 3 2%
United Kingdom 3 2%
Germany 2 1%
France 2 1%
Spain 2 1%
Portugal 2 1%
Argentina 2 1%
Australia 1 <1%
Other 4 3%
Unknown 131 83%

Demographic breakdown

Readers by professional status Count As %
Researcher 54 34%
Student > Ph. D. Student 29 18%
Student > Master 22 14%
Student > Bachelor 19 12%
Other 9 6%
Other 24 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 86 55%
Biochemistry, Genetics and Molecular Biology 29 18%
Medicine and Dentistry 10 6%
Computer Science 6 4%
Engineering 6 4%
Other 20 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 1728. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 June 2017.
All research outputs
#414
of 7,941,903 outputs
Outputs from Nature Communications
#3
of 12,332 outputs
Outputs of similar age
#44
of 286,187 outputs
Outputs of similar age from Nature Communications
#1
of 844 outputs
Altmetric has tracked 7,941,903 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 12,332 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 43.5. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 286,187 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 844 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.