Title |
Autosomal monoallelic expression in the mouse
|
---|---|
Published in |
Genome Biology, February 2012
|
DOI | 10.1186/gb-2012-13-2-r10 |
Pubmed ID | |
Authors |
Lillian M Zwemer, Alexander Zak, Benjamin R Thompson, Andrew Kirby, Mark J Daly, Andrew Chess, Alexander A Gimelbrant |
Abstract |
Random monoallelic expression defines an unusual class of genes displaying random choice for expression between the maternal and paternal alleles. Once established, the allele-specific expression pattern is stably maintained and mitotically inherited. Examples of random monoallelic genes include those found on the X-chromosome and a subset of autosomal genes, which have been most extensively studied in humans. Here, we report a genome-wide analysis of random monoallelic expression in the mouse. We used high density mouse genome polymorphism mapping arrays to assess allele-specific expression in clonal cell lines derived from heterozygous mouse strains. |
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Côte d'Ivoire | 1 | 14% |
United Kingdom | 1 | 14% |
Germany | 1 | 14% |
Spain | 1 | 14% |
Unknown | 1 | 14% |
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Scientists | 1 | 14% |
Science communicators (journalists, bloggers, editors) | 1 | 14% |
Mendeley readers
Geographical breakdown
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United Kingdom | 2 | 2% |
France | 1 | <1% |
Portugal | 1 | <1% |
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Unknown | 100 | 93% |
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Student > Ph. D. Student | 21 | 20% |
Professor > Associate Professor | 11 | 10% |
Professor | 10 | 9% |
Student > Master | 10 | 9% |
Other | 15 | 14% |
Unknown | 11 | 10% |
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Medicine and Dentistry | 7 | 7% |
Neuroscience | 3 | 3% |
Computer Science | 1 | <1% |
Other | 3 | 3% |
Unknown | 13 | 12% |