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Evolutionary diversification of the BetaM interactome acquired through co-option of the ATP1B4 gene in placental mammals

Overview of attention for article published in Scientific Reports, March 2016
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (84th percentile)
  • Good Attention Score compared to outputs of the same age and source (79th percentile)

Mentioned by

news
1 news outlet
twitter
1 tweeter

Citations

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4 Dimensions

Readers on

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12 Mendeley
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Title
Evolutionary diversification of the BetaM interactome acquired through co-option of the ATP1B4 gene in placental mammals
Published in
Scientific Reports, March 2016
DOI 10.1038/srep22395
Pubmed ID
Authors

Tatyana V. Korneenko, Nikolay B. Pestov, Nisar Ahmad, Irina A. Okkelman, Ruslan I. Dmitriev, Mikhail I. Shakhparonov, Nikolai N. Modyanov

Abstract

ATP1B4 genes represent a rare instance of orthologous vertebrate gene co-option that radically changed properties of the encoded BetaM proteins, which function as Na,K-ATPase subunits in lower vertebrates and birds. Eutherian BetaM has lost its ancestral function and became a muscle-specific resident of the inner nuclear membrane. Our earlier work implicated BetaM in regulation of gene expression through direct interaction with the transcriptional co-regulator SKIP. To gain insight into evolution of BetaM interactome we performed expanded screening of eutherian and avian cDNA libraries using yeast-two-hybrid and split-ubiquitin systems. The inventory of identified BetaM interactors includes lamina-associated protein LAP-1, myocyte nuclear envelope protein Syne1, BetaM itself, heme oxidases HMOX1 and HMOX2; transcription factor LZIP/CREB3, ERGIC3, PHF3, reticulocalbin-3, and β-sarcoglycan. No new interactions were found for chicken BetaM and human Na,K-ATPase β1, β2 and β3 isoforms, indicating the uniqueness of eutherian BetaM interactome. Analysis of truncated forms of BetaM indicates that residues 72-98 adjacent to the membrane in nucleoplasmic domain are important for the interaction with SKIP. These findings demonstrate that evolutionary alterations in structural and functional properties of eutherian BetaM proteins are associated with the increase in its interactome complexity.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Chile 1 8%
Unknown 11 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 33%
Professor 2 17%
Student > Bachelor 2 17%
Professor > Associate Professor 1 8%
Lecturer 1 8%
Other 0 0%
Unknown 2 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 5 42%
Environmental Science 1 8%
Mathematics 1 8%
Psychology 1 8%
Social Sciences 1 8%
Other 1 8%
Unknown 2 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 May 2016.
All research outputs
#794,020
of 7,684,314 outputs
Outputs from Scientific Reports
#5,930
of 30,153 outputs
Outputs of similar age
#43,116
of 283,169 outputs
Outputs of similar age from Scientific Reports
#627
of 3,054 outputs
Altmetric has tracked 7,684,314 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 30,153 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.9. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 283,169 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 3,054 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.