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4-Aminopyridine Induced Activity Rescues Hypoexcitable Motor Neurons from Amyotrophic Lateral Sclerosis Patient-Derived Induced Pluripotent Stem Cells

Overview of attention for article published in Stem Cells, March 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (86th percentile)
  • High Attention Score compared to outputs of the same age and source (86th percentile)

Mentioned by

news
1 news outlet
twitter
4 tweeters
facebook
2 Facebook pages

Citations

dimensions_citation
26 Dimensions

Readers on

mendeley
53 Mendeley
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Title
4-Aminopyridine Induced Activity Rescues Hypoexcitable Motor Neurons from Amyotrophic Lateral Sclerosis Patient-Derived Induced Pluripotent Stem Cells
Published in
Stem Cells, March 2016
DOI 10.1002/stem.2354
Pubmed ID
Authors

Maximilian Naujock, Nancy Stanslowsky, Sebastian Bufler, Marcel Naumann, Peter Reinhardt, Jared Sterneckert, Ekaterini Kefalakes, Carola Kassebaum, Franziska Bursch, Xenia Lojewski, Alexander Storch, Marie Frickenhaus, Tobias M. Boeckers, Stefan Putz, Maria Demestre, Stefan Liebau, Moritz Klingenstein, Albert C. Ludolph, Reinhard Dengler, Kwang-Soo Kim, Andreas Hermann, Florian Wegner, Susanne Petri

Abstract

Despite decades of research on amyotrophic lateral sclerosis (ALS), there is only one approved drug, which minimally extends patient survival. Here, we investigated pathophysiological mechanisms underlying ALS using motor neurons (MNs) differentiated from induced pluripotent stem cells (iPSCs) derived from ALS patients carrying mutations in FUS or SOD1. Patient-derived MNs were less active and excitable compared to healthy controls, due to reduced Na(+) /K(+) ratios in both ALS groups accompanied by elevated potassium receptor (FUS) and attenuated sodium receptor expression levels (FUS, SOD1). ALS iPSC-derived MNs showed elevated endoplasmic reticulum stress (ER) levels and increased caspase activation. Treatment with the FDA approved drug 4-Aminopyridine (4AP) restored ion-channel imbalances, increased neuronal activity levels and decreased ER stress and caspase activation. This study provides novel pathophysiological data, including a mechanistic explanation for the observed hypoexcitability in patient-derived MNs and a new therapeutic strategy to provide neuroprotection in MNs affected by ALS. This article is protected by copyright. All rights reserved.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 53 100%

Demographic breakdown

Readers by professional status Count As %
Unspecified 12 23%
Student > Ph. D. Student 11 21%
Student > Master 11 21%
Student > Bachelor 7 13%
Researcher 7 13%
Other 5 9%
Readers by discipline Count As %
Unspecified 14 26%
Agricultural and Biological Sciences 14 26%
Biochemistry, Genetics and Molecular Biology 9 17%
Neuroscience 9 17%
Medicine and Dentistry 6 11%
Other 1 2%

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 December 2017.
All research outputs
#1,380,643
of 13,474,817 outputs
Outputs from Stem Cells
#372
of 3,298 outputs
Outputs of similar age
#37,247
of 270,172 outputs
Outputs of similar age from Stem Cells
#16
of 117 outputs
Altmetric has tracked 13,474,817 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,298 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 270,172 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 117 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.