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RIM15 antagonistic pleiotropy is responsible for differences in fermentation and stress response kinetics in budding yeast

Overview of attention for article published in FEMS Yeast Research, March 2016
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Title
RIM15 antagonistic pleiotropy is responsible for differences in fermentation and stress response kinetics in budding yeast
Published in
FEMS Yeast Research, March 2016
DOI 10.1093/femsyr/fow021
Pubmed ID
Authors

Eduardo I. Kessi-Pérez, Sebastián Araos, Verónica García, Francisco Salinas, Valentina Abarca, Luis F. Larrondo, Claudio Martínez, Francisco A. Cubillos

Abstract

Different natural yeast populations have faced dissimilar selective pressures due to the heterogeneous fermentation substrates available around the world; this increases the genetic and phenotypic diversity in Saccharomyces cerevisiae. In this context, we expect prominent differences between isolates when exposed to a particular condition, such as wine or sake musts. To better comprehend the mechanisms underlying niche adaptation between two S. cerevisiae isolates obtained from wine and sake fermentation processes, we evaluated fermentative and fungicide resistance phenotypes and identify the molecular origin of such adaptive variation. Multiple regions were associated with fermentation rate under different nitrogen conditions and fungicide resistance, with a single QTL co-localising in all traits. Analysis around this region identified RIM15 as the causative locus driving fungicide sensitivity, together with efficient nitrogen utilisation and glycerol production in the wine strain. A null RIM15 variant confers a greater fermentation rate through the utilisation of available glucose instead of its storage. However this variant has a detrimental effect on fungicide resistance since complex sugars are not synthesized and transported into the membrane. Together, our results reveal the antagonist pleiotropic nature of a RIM15 null variant, positively affecting a series of fermentation related phenotypes, but apparently detrimental in the wild.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 4%
Unknown 27 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 21%
Researcher 6 21%
Professor > Associate Professor 5 18%
Other 4 14%
Student > Postgraduate 2 7%
Other 5 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 36%
Biochemistry, Genetics and Molecular Biology 6 21%
Medicine and Dentistry 4 14%
Unspecified 3 11%
Arts and Humanities 1 4%
Other 4 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 March 2016.
All research outputs
#10,664,820
of 12,024,798 outputs
Outputs from FEMS Yeast Research
#529
of 685 outputs
Outputs of similar age
#244,806
of 289,356 outputs
Outputs of similar age from FEMS Yeast Research
#28
of 32 outputs
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