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Plasmodium falciparum: multifaceted resistance to artemisinins

Overview of attention for article published in Malaria Journal, March 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (74th percentile)

Mentioned by

twitter
9 tweeters
facebook
1 Facebook page

Citations

dimensions_citation
48 Dimensions

Readers on

mendeley
206 Mendeley
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Title
Plasmodium falciparum: multifaceted resistance to artemisinins
Published in
Malaria Journal, March 2016
DOI 10.1186/s12936-016-1206-9
Pubmed ID
Authors

Lucie Paloque, Arba P. Ramadani, Odile Mercereau-Puijalon, Jean-Michel Augereau, Françoise Benoit-Vical

Abstract

Plasmodium falciparum resistance to artemisinins, the most potent and fastest acting anti-malarials, threatens malaria elimination strategies. Artemisinin resistance is due to mutation of the PfK13 propeller domain and involves an unconventional mechanism based on a quiescence state leading to parasite recrudescence as soon as drug pressure is removed. The enhanced P. falciparum quiescence capacity of artemisinin-resistant parasites results from an increased ability to manage oxidative damage and an altered cell cycle gene regulation within a complex network involving the unfolded protein response, the PI3K/PI3P/AKT pathway, the PfPK4/eIF2α cascade and yet unidentified transcription factor(s), with minimal energetic requirements and fatty acid metabolism maintained in the mitochondrion and apicoplast. The detailed study of these mechanisms offers a way forward for identifying future intervention targets to fend off established artemisinin resistance.

Twitter Demographics

The data shown below were collected from the profiles of 9 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 206 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Madagascar 1 <1%
Nigeria 1 <1%
Unknown 204 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 44 21%
Student > Ph. D. Student 43 21%
Student > Bachelor 28 14%
Researcher 25 12%
Student > Doctoral Student 15 7%
Other 32 16%
Unknown 19 9%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 61 30%
Agricultural and Biological Sciences 39 19%
Medicine and Dentistry 27 13%
Pharmacology, Toxicology and Pharmaceutical Science 18 9%
Chemistry 17 8%
Other 22 11%
Unknown 22 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 August 2016.
All research outputs
#3,008,342
of 12,502,636 outputs
Outputs from Malaria Journal
#903
of 3,653 outputs
Outputs of similar age
#69,344
of 268,774 outputs
Outputs of similar age from Malaria Journal
#2
of 3 outputs
Altmetric has tracked 12,502,636 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,653 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 268,774 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one.