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Attention Score in Context
| Title |
Insulin improves memory and reduces chronic neuroinflammation in the hippocampus of young but not aged brains
|
|---|---|
| Published in |
Journal of Neuroinflammation, April 2015
|
| DOI | 10.1186/s12974-015-0282-z |
| Pubmed ID | |
| Authors |
Linda Adzovic, Ashley E Lynn, Heather M D’Angelo, Alexis M Crockett, Roxanne M Kaercher, Sarah E Royer, Sarah C Hopp, Gary L Wenk |
| Abstract |
The role of insulin in the brain is still not completely understood. In the periphery, insulin can decrease inflammation induced by lipopolysaccharide (LPS); however, whether insulin can reduce inflammation within the brain is unknown. Experiments administrating intranasal insulin to young and aged adults have shown that insulin improves memory. In our animal model of chronic neuroinflammation, we administered insulin and/or LPS directly into the brain via the fourth ventricle for 4 weeks in young rats; we then analyzed their spatial memory and neuroinflammatory response. Additionally, we administered insulin or artificial cerebral spinal fluid (aCSF), in the same manner, to aged rats and then analyzed their spatial memory and neuroinflammatory response. Response to chronic neuroinflammation in young rats was analyzed in the presence or absence of insulin supplementation. Here, we show for the first time that insulin infused (i.c.v.) to young rats significantly attenuated the effects of LPS by decreasing the expression of neuroinflammatory markers in the hippocampus and by improving performance in the Morris water pool task. In young rats, insulin infusion alone significantly improved their performance as compared to all other groups. Unexpectedly, in aged rats, the responsiveness to insulin was completely absent, that is, spatial memory was still impaired suggesting that an age-dependent insulin resistance may contribute to the cognitive impairment observed in neurodegenerative diseases. Our data suggest a novel therapeutic effect of insulin on neuroinflammation in the young but not the aged brain. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 75 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 23% |
| Student > Bachelor | 17 | 23% |
| Researcher | 8 | 11% |
| Student > Master | 5 | 7% |
| Other | 4 | 5% |
| Other | 10 | 13% |
| Unknown | 14 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 14 | 19% |
| Agricultural and Biological Sciences | 11 | 15% |
| Pharmacology, Toxicology and Pharmaceutical Science | 8 | 11% |
| Biochemistry, Genetics and Molecular Biology | 7 | 9% |
| Psychology | 6 | 8% |
| Other | 15 | 20% |
| Unknown | 14 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 March 2016.
All research outputs
#20,313,158
of 22,854,458 outputs
Outputs from Journal of Neuroinflammation
#2,314
of 2,642 outputs
Outputs of similar age
#223,318
of 263,802 outputs
Outputs of similar age from Journal of Neuroinflammation
#48
of 50 outputs
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