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19p13.1 is a triple negative-specific breast cancer susceptibility locus.

Overview of attention for article published in Cancer Research, February 2012
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Title
19p13.1 is a triple negative-specific breast cancer susceptibility locus.
Published in
Cancer Research, February 2012
DOI 10.1158/0008-5472.can-11-3364
Pubmed ID
Authors

Stevens KN, Fredericksen Z, Vachon CM, Wang X, Margolin S, Lindblom A, Nevanlinna H, Greco D, Aittomäki K, Blomqvist C, Chang-Claude J, Vrieling A, Flesch-Janys D, Sinn HP, Wang-Gohrke S, Nickels S, Brauch H, Ko YD, Fischer HP, Network TG, Schmutzler RK, Meindl A, Bartram CR, Schott S, Engel C, Godwin AK, Weaver J, Pathak HB, Sharma P, Brenner H, Muller H, Arndt V, Stegmaier C, Miron P, Yannoukakos D, Stavropoulou A, Fountzilas G, Gogas HJ, Swann R, Dwek M, Perkins KA, Milne RL, Benítez J, Zamora MP, Ignacio Arias Pérez J, Bojesen SE, Nielsen SF, Nordestgaard BG, Flyger H, Guénel P, Truong T, Menegaux F, Cordina-Duverger E, Burwinkel B, Marmé F, Schneeweiss A, Sohn C, Sawyer E, Tomlinson I, Kerin MJ, Peto J, Johnson N, Fletcher O, Dos Santos Silva I, Fasching PA, Beckmann MW, Hartmann A, Ekici AB, Lophatananon A, Muir K, Puttawibul P, Wiangnon S, Schmidt MK, Broeks A, Braaf LM, Rosenberg EH, Hopper JL, Apicella C, Park DJ, Southey MC, Swerdlow AJ, Ashworth A, Orr N, Schoemaker MJ, Anton-Culver H, Ziogas A, Bernstein L, Clarke Dur C, Shen CY, Yu JC, Hsu HM, Hsiung CN, Hamann U, Dünnebier T, Rüdiger T, Ulrich Ulmer H, Pharoah PD, Dunning AM, Humphreys MK, Wang Q, Cox A, Cross SS, Reed MW, Hall P, Czene K, Ambrosone CB, Ademuyiwa F, Hwang H, Eccles DM, Garcia-Closas M, Figueroa JD, Sherman ME, Lissowska J, Devilee P, Seynaeve C, Tollenaar RA, Hooning MJ, Andrulis IL, Knight JA, Glendon G, Mulligan AM, Winqvist R, Pylkäs K, Jukkola-Vuorinen A, Grip M, John EM, Miron A, Grenaker Alnaes G, Kristensen V, Borresen-Dale AL, Giles GG, Baglietto L, McLean CA, Severi G, Kosel ML, Pankratz VS, Slager S, Olson JE, Radice P, Peterlongo P, Manoukian S, Barile M, Lambrechts D, Hatse S, Dieudonne AS, Christiaens MR, Chenevix-Trench G, Investigators K, Group A, Beesley J, Chen X, Mannermaa A, Kosma VM, Hartikainen JM, Soini Y, Easton DF, Couch FJ, K. N. Stevens, Z. Fredericksen, C. M. Vachon, X. Wang, S. Margolin, A. Lindblom, H. Nevanlinna, D. Greco, K. Aittomaki, C. Blomqvist, J. Chang-Claude, A. Vrieling, D. Flesch-Janys, H.-P. Sinn, S. Wang-Gohrke, S. Nickels, H. Brauch, Y.-D. Ko, H.-P. Fischer, R. K. Schmutzler, A. Meindl, C. R. Bartram, S. Schott, C. Engel, A. K. Godwin, J. Weaver, H. B. Pathak, P. Sharma, H. Brenner, H. Muller, V. Arndt, C. Stegmaier, P. Miron, D. Yannoukakos, A. Stavropoulou, G. Fountzilas, H. J. Gogas, R. Swann, M. Dwek, A. Perkins, R. L. Milne, J. Benitez, M. P. Zamora, J. I. A. Perez, S. E. Bojesen, S. F. Nielsen, B. G. Nordestgaard, H. Flyger, P. Guenel, T. Truong, F. Menegaux, E. Cordina-Duverger, B. Burwinkel, F. Marme, A. Schneeweiss, C. Sohn, E. Sawyer, I. Tomlinson, M. J. Kerin, J. Peto, N. Johnson, O. Fletcher, I. dos Santos Silva, P. A. Fasching, M. W. Beckmann, A. Hartmann, A. B. Ekici, A. Lophatananon, K. Muir, P. Puttawibul, S. Wiangnon, M. K. Schmidt, A. Broeks, L. M. Braaf, E. H. Rosenberg, J. L. Hopper, C. Apicella, D. J. Park, M. C. Southey, A. J. Swerdlow, A. Ashworth, N. Orr, M. J. Schoemaker, H. Anton-Culver, A. Ziogas, L. Bernstein, C. C. Dur, C.-Y. Shen, J.-C. Yu, H.-M. Hsu, C.-N. Hsiung, U. Hamann, T. Dunnebier, T. Rudiger, H. U. Ulmer, P. P. Pharoah, A. M. Dunning, M. K. Humphreys, Q. Wang, A. Cox, S. S. Cross, M. W. Reed, P. Hall, K. Czene, C. B. Ambrosone, F. Ademuyiwa, H. Hwang, D. M. Eccles, M. Garcia-Closas, J. D. Figueroa, M. E. Sherman, J. Lissowska, P. Devilee, C. Seynaeve, R. A. E. M. Tollenaar, M. J. Hooning, I. L. Andrulis, J. A. Knight, G. Glendon, A. M. Mulligan, R. Winqvist, K. Pylkas, A. Jukkola-Vuorinen, M. Grip, E. M. John, A. Miron, G. G. Alnaes, V. Kristensen, A.-L. Borresen-Dale, G. G. Giles, L. Baglietto, C. A. McLean, G. Severi, M. L. Kosel, V. S. Pankratz, S. Slager, J. E. Olson, P. Radice, P. Peterlongo, S. Manoukian, M. Barile, D. Lambrechts, S. Hatse, A.-S. Dieudonne, M.-R. Christiaens, G. Chenevix-Trench, J. Beesley, X. Chen, A. Mannermaa, V.-M. Kosma, J. M. Hartikainen, Y. Soini, D. F. Easton, F. J. Couch

Abstract

The 19p13.1 breast cancer susceptibility locus is a modifier of breast cancer risk in BRCA1 mutation carriers and is also associated with the risk of ovarian cancer. Here, we investigated 19p13.1 variation and risk of breast cancer subtypes, defined by estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER2) status, using 48,869 breast cancer cases and 49,787 controls from the Breast Cancer Association Consortium (BCAC). Variants from 19p13.1 were not associated with breast cancer overall or with ER-positive breast cancer but were significantly associated with ER-negative breast cancer risk [rs8170 OR, 1.10; 95% confidence interval (CI), 1.05-1.15; P = 3.49 × 10(-5)] and triple-negative (ER-, PR-, and HER2-negative) breast cancer (rs8170: OR, 1.22; 95% CI, 1.13-1.31; P = 2.22 × 10(-7)). However, rs8170 was no longer associated with ER-negative breast cancer risk when triple-negative cases were excluded (OR, 0.98; 95% CI, 0.89-1.07; P = 0.62). In addition, a combined analysis of triple-negative cases from BCAC and the Triple Negative Breast Cancer Consortium (TNBCC; N = 3,566) identified a genome-wide significant association between rs8170 and triple-negative breast cancer risk (OR, 1.25; 95% CI, 1.18-1.33; P = 3.31 × 10(-13)]. Thus, 19p13.1 is the first triple-negative-specific breast cancer risk locus and the first locus specific to a histologic subtype defined by ER, PR, and HER2 to be identified. These findings provide convincing evidence that genetic susceptibility to breast cancer varies by tumor subtype and that triple-negative tumors and other subtypes likely arise through distinct etiologic pathways.

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Mendeley readers

The data shown below were compiled from readership statistics for 93 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Belgium 2 2%
United Kingdom 2 2%
Brazil 1 1%
Japan 1 1%
United States 1 1%
Unknown 86 92%

Demographic breakdown

Readers by professional status Count As %
Researcher 24 26%
Student > Ph. D. Student 14 15%
Professor > Associate Professor 12 13%
Professor 10 11%
Other 9 10%
Other 14 15%
Unknown 10 11%
Readers by discipline Count As %
Medicine and Dentistry 30 32%
Agricultural and Biological Sciences 29 31%
Biochemistry, Genetics and Molecular Biology 10 11%
Engineering 3 3%
Chemistry 3 3%
Other 4 4%
Unknown 14 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 April 2012.
All research outputs
#4,821,526
of 8,904,442 outputs
Outputs from Cancer Research
#5,357
of 7,916 outputs
Outputs of similar age
#46,302
of 96,952 outputs
Outputs of similar age from Cancer Research
#24
of 55 outputs
Altmetric has tracked 8,904,442 research outputs across all sources so far. This one is in the 27th percentile – i.e., 27% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,916 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.7. This one is in the 18th percentile – i.e., 18% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 96,952 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 55 others from the same source and published within six weeks on either side of this one. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.