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Spatiotemporal patterns of sortilin and SorCS2 localization during organ development

Overview of attention for article published in BMC Molecular and Cell Biology, March 2016
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Title
Spatiotemporal patterns of sortilin and SorCS2 localization during organ development
Published in
BMC Molecular and Cell Biology, March 2016
DOI 10.1186/s12860-016-0085-9
Pubmed ID
Authors

Simon Boggild, Simon Molgaard, Simon Glerup, Jens Randel Nyengaard

Abstract

Sortilin and SorCS2 are part of the Vps10p receptor family. They have both been studied in nervous tissue with several important functions revealed, while their expression and possible functions in developing peripheral tissue remain poorly understood. Here we deliver a thorough characterization of the prenatal localization of sortilin and SorCS2 in mouse peripheral tissue. Sortilin is highly expressed in epithelial tissues of the developing lung, nasal cavity, kidney, pancreas, salivary gland and developing intrahepatic bile ducts. Furthermore tissues such as the thyroid gland, developing cartilage and ossifying bone also show high expression of sortilin together with cell types such as megakaryocytes in the liver. SorCS2 is primarily expressed in mesodermally derived tissues such as striated muscle, adipose tissue, ossifying bone and general connective tissue throughout the body, as well as in lung epithelia. Furthermore, the adrenal gland and liver show high expression of SorCS2 in embryos 13.5 days old. The possible functions relating to the expression patterns of Sortilin and SorCS2 in development are numerous and hopefully this paper will help to generate new hypotheses to further our understanding of the Vps10p receptor family.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 3%
Unknown 35 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 17%
Student > Bachelor 5 14%
Student > Master 5 14%
Researcher 4 11%
Student > Doctoral Student 2 6%
Other 2 6%
Unknown 12 33%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 9 25%
Neuroscience 5 14%
Agricultural and Biological Sciences 4 11%
Medicine and Dentistry 3 8%
Sports and Recreations 1 3%
Other 1 3%
Unknown 13 36%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 March 2016.
All research outputs
#22,759,802
of 25,374,917 outputs
Outputs from BMC Molecular and Cell Biology
#1,054
of 1,233 outputs
Outputs of similar age
#271,078
of 314,783 outputs
Outputs of similar age from BMC Molecular and Cell Biology
#16
of 19 outputs
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So far Altmetric has tracked 1,233 research outputs from this source. They receive a mean Attention Score of 4.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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