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Immunohistochemical expression of glucose transporter 1 in keratin-producing odontogenic cysts

Overview of attention for article published in BMC Oral Health, March 2016
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Title
Immunohistochemical expression of glucose transporter 1 in keratin-producing odontogenic cysts
Published in
BMC Oral Health, March 2016
DOI 10.1186/s12903-016-0191-2
Pubmed ID
Authors

Beatriz Vera-Sirera, Leopoldo Forner-Navarro, Francisco Vera-Sempere

Abstract

Keratin-producing odontogenic cysts (KPOCs) are a group of cystic lesions that are often aggressive, with high rates of recurrence and multifocality. KPOCs included orthokeratinised odontogenic cyst (OOC) and parakeratotic odontogenic cysts, which are now considered true tumours denominated keratocystic odontogenic tumours (KCOTs). GLUT1 is a protein transporter that is involved in the active uptake of glucose across cell membranes and that is overexpressed in tumours in close correlation with the proliferation rate and positron emission tomography (PET) imaging results. A series of 58 keratin-producing odontogenic cysts was evaluated histologically and immunohistochemically in terms of GLUT1 expression. Different data were correlated using the beta regression model in relation to histological type and immunohistochemical expression of GLUT1, which was quantified using two different morphological methods. KPOC cases comprised 12 OOCs and 46 KCOTs, the latter corresponding to 6 syndromic and 40 sporadic KCOTs. GLUT1 expression was very low in OOC cases compared with KCOT cases, with statistical significant differences when quantification was considered. Different GLUT1 localisation patterns were revealed by immunostaining, with the parabasal cells showing higher reactivity in KCOTs. However, among KCOTs cases, GLUT1 expression was unable to establish differences between syndromic and sporadic cases. GLUT1 expression differentiated between OOC and KCOT cases, with significantly higher expression in KCOTs, but did not differentiate between syndromic and sporadic KCOT cases. However, given the structural characteristics of KCOTs, we hypothesised that PET imaging methodology is probably not a useful diagnostic tool for KCOTs. Further studies of GLUT1 expression and PET examination in KCOT series are needed to confirm this last hypothesis.

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Mendeley readers

The data shown below were compiled from readership statistics for 7 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 14%
Unknown 6 86%

Demographic breakdown

Readers by professional status Count As %
Professor 1 14%
Other 1 14%
Student > Ph. D. Student 1 14%
Unspecified 1 14%
Unknown 3 43%
Readers by discipline Count As %
Medicine and Dentistry 2 29%
Unspecified 1 14%
Design 1 14%
Unknown 3 43%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 March 2016.
All research outputs
#6,387,326
of 7,382,271 outputs
Outputs from BMC Oral Health
#367
of 420 outputs
Outputs of similar age
#234,321
of 277,277 outputs
Outputs of similar age from BMC Oral Health
#27
of 39 outputs
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