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| Chapter title |
Optogenetic Control of Fibroblast Growth Factor Receptor Signaling
|
|---|---|
| Chapter number | 24 |
| Book title |
Optogenetics
|
| Published in |
Methods in molecular biology, March 2016
|
| DOI | 10.1007/978-1-4939-3512-3_24 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-3510-9, 978-1-4939-3512-3
|
| Authors |
Nury Kim, Jin Man Kim, Won Do Heo |
| Editors |
Arash Kianianmomeni |
| Abstract |
FGFR1 is a member of the fibroblast growth factor family, which controls diverse cellular functions such as cell proliferation, migration, and differentiation. OptoFGFR1, an optogenetic method to modulate the FGFR signaling pathway with light by utilizing PHR domain of cryptochrome2 and cytoplasmic region of FGFR1, enabled light-guided activation of FGFR to study its effects on downstream signaling pathway and during diverse biological processes such as cell migration. Here, we describe about optogenetic and microscopic methods to spatiotemporally manipulate FGFR signaling in a single cell or group of cells using confocal microscope and LED array. |
Mendeley readers
The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 10% |
| Unknown | 9 | 90% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 6 | 60% |
| Professor > Associate Professor | 1 | 10% |
| Student > Master | 1 | 10% |
| Unknown | 2 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 5 | 50% |
| Medicine and Dentistry | 2 | 20% |
| Agricultural and Biological Sciences | 1 | 10% |
| Unknown | 2 | 20% |