Chapter title |
Optogenetic Tools for Confined Stimulation in Deep Brain Structures
|
---|---|
Chapter number | 18 |
Book title |
Optogenetics
|
Published in |
Methods in molecular biology, March 2016
|
DOI | 10.1007/978-1-4939-3512-3_18 |
Pubmed ID | |
Book ISBNs |
978-1-4939-3510-9, 978-1-4939-3512-3
|
Authors |
Alexandre Castonguay, Sébastien Thomas, Frédéric Lesage, Christian Casanova |
Editors |
Arash Kianianmomeni |
Abstract |
Optogenetics has emerged in the past decade as a technique to modulate brain activity with cell-type specificity and with high temporal resolution. Among the challenges associated with this technique is the difficulty to target a spatially restricted neuron population. Indeed, light absorption and scattering in biological tissues make it difficult to illuminate a minute volume, especially in the deep brain, without the use of optical fibers to guide light. This work describes the design and the in vivo application of a side-firing optical fiber adequate for delivering light to specific regions within a brain subcortical structure. |
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