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Optogenetics

Overview of attention for book
Cover of 'Optogenetics'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 Optogenetics
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    Chapter 2 Optogenetics
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    Chapter 3 Optogenetics
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    Chapter 4 Reversible Photoregulation of Gene Expression and Translation
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    Chapter 5 Controlling Protein Activity and Degradation Using Blue Light.
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    Chapter 6 Photo Control of Protein Function Using Photoactive Yellow Protein
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    Chapter 7 Optogenetics
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    Chapter 8 Optogenetic Control of Pancreatic Islets
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    Chapter 9 Optogenetics in Plants: Red/Far-Red Light Control of Gene Expression
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    Chapter 10 Optogenetics
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    Chapter 11 Optogenetics
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    Chapter 12 Optogenetic Control of Mammalian Ion Channels with Chemical Photoswitches
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    Chapter 13 Optogenetic Modulation of Locomotor Activity on Free-Behaving Rats
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    Chapter 14 Combined Optogenetic and Chemogenetic Control of Neurons
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    Chapter 15 Intracranial Injection of an Optogenetics Viral Vector Followed by Optical Cannula Implantation for Neural Stimulation in Rat Brain Cortex
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    Chapter 16 An Optimized Calcium-Phosphate Transfection Method for Characterizing Genetically Encoded Tools in Primary Neurons
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    Chapter 17 Optogenetic Approaches for Mesoscopic Brain Mapping
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    Chapter 18 Optogenetic Tools for Confined Stimulation in Deep Brain Structures
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    Chapter 19 Optogenetics
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    Chapter 20 Optogenetic Light Crafting Tools for the Control of Cardiac Arrhythmias
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    Chapter 21 Inscribing Optical Excitability to Non-Excitable Cardiac Cells: Viral Delivery of Optogenetic Tools in Primary Cardiac Fibroblasts
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    Chapter 22 Optogenetic Engineering of Atrial Cardiomyocytes
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    Chapter 23 A Multichannel Recording System with Optical Stimulation for Closed-Loop Optogenetic Experiments
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    Chapter 24 Optogenetic Control of Fibroblast Growth Factor Receptor Signaling
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    Chapter 25 Protein Inactivation by Optogenetic Trapping in Living Cells
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    Chapter 26 Optogenetics
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    Chapter 27 Guidelines for Photoreceptor Engineering
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    Chapter 28 Erratum to: Optogenetics in Plants: Red/Far-Red Light Control of Gene Expression
Attention for Chapter 14: Combined Optogenetic and Chemogenetic Control of Neurons
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Chapter title
Combined Optogenetic and Chemogenetic Control of Neurons
Chapter number 14
Book title
Optogenetics
Published in
Methods in molecular biology, March 2016
DOI 10.1007/978-1-4939-3512-3_14
Pubmed ID
Book ISBNs
978-1-4939-3510-9, 978-1-4939-3512-3
Authors

Ken Berglund, Jack K. Tung, Bryan Higashikubo, Robert E. Gross, Christopher I. Moore, Ute Hochgeschwender

Editors

Arash Kianianmomeni

Abstract

Optogenetics provides an array of elements for specific biophysical control, while designer chemogenetic receptors provide a minimally invasive method to control circuits in vivo by peripheral injection. We developed a strategy for selective regulation of activity in specific cells that integrates opto- and chemogenetic approaches, and thus allows manipulation of neuronal activity over a range of spatial and temporal scales in the same experimental animal. Light-sensing molecules (opsins) are activated by biologically produced light through luciferases upon peripheral injection of a small molecule substrate. Such luminescent opsins, luminopsins, allow conventional fiber optic use of optogenetic sensors, while at the same time providing chemogenetic access to the same sensors. We describe applications of this approach in cultured neurons in vitro, in brain slices ex vivo, and in awake and anesthetized animals in vivo.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 41 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 18 44%
Student > Bachelor 8 20%
Researcher 4 10%
Student > Master 2 5%
Professor > Associate Professor 2 5%
Other 2 5%
Unknown 5 12%
Readers by discipline Count As %
Neuroscience 14 34%
Agricultural and Biological Sciences 7 17%
Biochemistry, Genetics and Molecular Biology 4 10%
Medicine and Dentistry 4 10%
Engineering 3 7%
Other 2 5%
Unknown 7 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 October 2020.
All research outputs
#14,333,725
of 16,251,239 outputs
Outputs from Methods in molecular biology
#6,562
of 9,395 outputs
Outputs of similar age
#230,040
of 268,509 outputs
Outputs of similar age from Methods in molecular biology
#20
of 35 outputs
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So far Altmetric has tracked 9,395 research outputs from this source. They receive a mean Attention Score of 2.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 35 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.