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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Targeting neurotransmitter receptors with nanoparticles in vivo allows single-molecule tracking in acute brain slices
|
|---|---|
| Published in |
Nature Communications, March 2016
|
| DOI | 10.1038/ncomms10947 |
| Pubmed ID | |
| Authors |
Juan A. Varela, Julien P. Dupuis, Laetitia Etchepare, Agnès Espana, Laurent Cognet, Laurent Groc |
| Abstract |
Single-molecule imaging has changed the way we understand many biological mechanisms, particularly in neurobiology, by shedding light on intricate molecular events down to the nanoscale. However, current single-molecule studies in neuroscience have been limited to cultured neurons or organotypic slices, leaving as an open question the existence of fast receptor diffusion in intact brain tissue. Here, for the first time, we targeted dopamine receptors in vivo with functionalized quantum dots and were able to perform single-molecule tracking in acute rat brain slices. We propose a novel delocalized and non-inflammatory way of delivering nanoparticles (NPs) in vivo to the brain, which allowed us to label and track genetically engineered surface dopamine receptors in neocortical neurons, revealing inherent behaviour and receptor activity regulations. We thus propose a NP-based platform for single-molecule studies in the living brain, opening new avenues of research in physiological and pathological animal models. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 33% |
| United Kingdom | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 156 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 3 | 2% |
| Germany | 2 | 1% |
| United States | 2 | 1% |
| Unknown | 149 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 42 | 27% |
| Student > Ph. D. Student | 31 | 20% |
| Student > Bachelor | 14 | 9% |
| Student > Master | 13 | 8% |
| Student > Doctoral Student | 9 | 6% |
| Other | 25 | 16% |
| Unknown | 22 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 37 | 24% |
| Agricultural and Biological Sciences | 26 | 17% |
| Chemistry | 15 | 10% |
| Biochemistry, Genetics and Molecular Biology | 12 | 8% |
| Engineering | 11 | 7% |
| Other | 31 | 20% |
| Unknown | 24 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 April 2020.
All research outputs
#15,807,427
of 25,470,300 outputs
Outputs from Nature Communications
#48,188
of 57,208 outputs
Outputs of similar age
#165,974
of 314,722 outputs
Outputs of similar age from Nature Communications
#695
of 871 outputs
Altmetric has tracked 25,470,300 research outputs across all sources so far. This one is in the 36th percentile – i.e., 36% of other outputs scored the same or lower than it.
So far Altmetric has tracked 57,208 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.6. This one is in the 14th percentile – i.e., 14% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 314,722 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 871 others from the same source and published within six weeks on either side of this one. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.