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Primary systemic amyloidosis initially presenting with digestive symptoms: a case report and review of the literature

Overview of attention for article published in Diagnostic Pathology, September 2015
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Title
Primary systemic amyloidosis initially presenting with digestive symptoms: a case report and review of the literature
Published in
Diagnostic Pathology, September 2015
DOI 10.1186/s13000-015-0407-9
Pubmed ID
Authors

Xiu Lin, Yueping Mao, Qing Qi, Chuyi Zhang, Yongzhen Tian, Yanyang Chen

Abstract

Primary systemic amyloidosis (PSA) is one of systemic amyloidosis, characterized by clonal plasma cell disorder. The disease is rare and with high fatality. Signs and symptoms of PSA are various and complex, which depend on the organs involved. Here we report a case in which the patient initially suffered from gastrointestinal symptoms. Gradually periorbital purpura, skin fragility, and subsequent petechiae, ecchymoses and sclerosis of the distal limbs, appeared. Biopsy of his palmar skin showed scleroderma-like changes. However, histopathology of the petechiae lesion on forehead with Crystal Violet Staining prompted deposition of amyloid; gastric mucosal biopsy with Congo Red staining was also positive, which made clear the diagnosis of PSA. Bone marrow biopsy and serum immunofixation electrophoresis (IFE) revealed plasmacytosis and M proteinemia. Other examinations were performed to assess the function of organs. PSA was challenging due to the initial atypical clinical presentation and absence of biopsy with special staining. The case demonstrates that PSA should be considered in patients with multisystemic symptoms and biopsy with Congo Red staining should be performed to exclusively diagnose amyloidosis.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 15 100%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 3 20%
Student > Master 3 20%
Researcher 2 13%
Other 1 7%
Lecturer > Senior Lecturer 1 7%
Other 3 20%
Unknown 2 13%
Readers by discipline Count As %
Medicine and Dentistry 10 67%
Chemical Engineering 1 7%
Neuroscience 1 7%
Nursing and Health Professions 1 7%
Unknown 2 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 March 2016.
All research outputs
#20,315,221
of 22,856,968 outputs
Outputs from Diagnostic Pathology
#948
of 1,129 outputs
Outputs of similar age
#230,271
of 274,318 outputs
Outputs of similar age from Diagnostic Pathology
#33
of 39 outputs
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