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Differential plasma protein binding to metal oxide nanoparticles

Overview of attention for article published in Nanotechnology, October 2009
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (86th percentile)
  • High Attention Score compared to outputs of the same age and source (83rd percentile)

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1 blog


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173 Mendeley
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Differential plasma protein binding to metal oxide nanoparticles
Published in
Nanotechnology, October 2009
DOI 10.1088/0957-4484/20/45/455101
Pubmed ID

Zhou J Deng, Gysell Mortimer, Tara Schiller, Anthony Musumeci, Darren Martin, Rodney F Minchin


Nanoparticles rapidly interact with the proteins present in biological fluids, such as blood. The proteins that are adsorbed onto the surface potentially dictate the biokinetics of the nanomaterials and their fate in vivo. Using nanoparticles with different sizes and surface characteristics, studies have reported the effects of physicochemical properties on the composition of adsorbed plasma proteins. However, to date, few studies have been conducted focusing on the nanoparticles that are commonly exposed to the general public, such as the metal oxides. Using previously established ultracentrifugation approaches, two-dimensional gel electrophoresis and mass spectrometry, the current study investigated the binding of human plasma proteins to commercially available titanium dioxide, silicon dioxide and zinc oxide nanoparticles. We found that, despite these particles having similar surface charges in buffer, they bound different plasma proteins. For TiO2, the shape of the nanoparticles was also an important determinant of protein binding. Agglomeration in water was observed for all of the nanoparticles and both TiO2 and ZnO further agglomerated in biological media. This led to an increase in the amount and number of different proteins bound to these nanoparticles. Proteins with important biological functions were identified, including immunoglobulins, lipoproteins, acute-phase proteins and proteins involved in complement pathways and coagulation. These results provide important insights into which human plasma proteins bind to particular metal oxide nanoparticles. Because protein absorption to nanoparticles may determine their interaction with cells and tissues in vivo, understanding how and why plasma proteins are adsorbed to these particles may be important for understanding their biological responses.

Mendeley readers

The data shown below were compiled from readership statistics for 173 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 2%
India 3 2%
South Africa 1 <1%
France 1 <1%
Australia 1 <1%
Germany 1 <1%
United Kingdom 1 <1%
Italy 1 <1%
Poland 1 <1%
Other 2 1%
Unknown 158 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 60 35%
Student > Master 30 17%
Researcher 28 16%
Unspecified 12 7%
Student > Bachelor 11 6%
Other 32 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 40 23%
Chemistry 37 21%
Unspecified 23 13%
Materials Science 14 8%
Engineering 14 8%
Other 45 26%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 February 2012.
All research outputs
of 4,011,222 outputs
Outputs from Nanotechnology
of 878 outputs
Outputs of similar age
of 77,479 outputs
Outputs of similar age from Nanotechnology
of 49 outputs
Altmetric has tracked 4,011,222 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 878 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 77,479 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 49 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.