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Mendeley readers
Attention Score in Context
| Title |
Low Ten-eleven-translocation 2 (TET2) transcript level is independent of TET2 mutation in patients with myeloid neoplasms
|
|---|---|
| Published in |
Diagnostic Pathology, March 2016
|
| DOI | 10.1186/s13000-016-0476-4 |
| Pubmed ID | |
| Authors |
Renata Scopim-Ribeiro, João Agostinho Machado-Neto, Paula de Melo Campos, Fernanda Soares Niemann, Irene Lorand-Metze, Fernando Ferreira Costa, Sara Teresinha Olalla Saad, Fabiola Traina |
| Abstract |
New sequencing technologies have enabled the identification of mutations in Ten-eleven-translocation 2 (TET2), an enzyme that catalyzes the conversion of 5-methylcytosine into 5-hydroxymethylcytosine (5-hmC) in myeloid neoplasms. We have recently identified reduced TET2 mRNA expression in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), which is associated with a poor overall survival in MDS. We herein aimed to investigate TET2 mutations and their impact on TET2 expression in a cohort of patients with myeloid neoplasms, including MDS and AML patients. TET2 mutations were observed in 8 out of 19 patients (42 %) with myeloid neoplasms. The TET2 expression profile was similar between in wild type and in TET2 mutated patients. Our results suggest that TET2 expression is reduced in MDS/AML patients, independently of mutational status. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 19 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 4 | 21% |
| Researcher | 4 | 21% |
| Student > Ph. D. Student | 3 | 16% |
| Other | 2 | 11% |
| Student > Doctoral Student | 2 | 11% |
| Other | 4 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 8 | 42% |
| Medicine and Dentistry | 4 | 21% |
| Nursing and Health Professions | 2 | 11% |
| Agricultural and Biological Sciences | 2 | 11% |
| Economics, Econometrics and Finance | 2 | 11% |
| Other | 1 | 5% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 March 2016.
All research outputs
#16,720,137
of 25,371,288 outputs
Outputs from Diagnostic Pathology
#531
of 1,193 outputs
Outputs of similar age
#182,284
of 314,933 outputs
Outputs of similar age from Diagnostic Pathology
#11
of 22 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,193 research outputs from this source. They receive a mean Attention Score of 3.4. This one has gotten more attention than average, scoring higher than 51% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 314,933 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.